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. 2020 Feb 18;17:8. doi: 10.1186/s12950-020-0234-y

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — CircRNA-CDR1as play a role in human OA chondrocytes. a Normal chondrocytes were transfected with circRNA-CDR1as siRNA. The expression level of circRNA-CDR1as was analyzed by qRT-PCR. b-c OA chondrocytes were transfected with circRNA-CDR1as siRNA or p-circRNA-CDR1as. Col II, MMP13 and IL-6 levels were analyzed by qRT-PCR and western blot. d Following transfection of siRNA, expression of COL II and MMP13 were assessed by immunofluorescence. Scale bar, 100 μm. Data are expressed as mean + SEM. *p < 0.05 (t-test). Shown are the representative results from at least 3 independent experiments