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. 2020 Feb 18;17:8. doi: 10.1186/s12950-020-0234-y

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — circRNA-CDR1as regulates the level of type II collagen, MMP13 and IL-6. a Changes in miR-641 abundance upon transfection with miR-641 inhibitors. MiR-641 abundance was determined by qRT-PCR. b-c The levels of MMP13, Col II and IL-6 were detected following transfection with circRNA-CDR1as, co-transfection with circRNA-CDR1as and the miR-641 inhibitor in chondrocytes. b The mRNA levels of MMP13, Col II and IL-6 were assessed by qRT-PCR. c The levels of MMP13 and Col II proteins were detected by western blot. Data are expressed as mean + SEM (n = 3). *p < 0.05 (t-test)