Fig. 6.

Endotoxemia-elicited neurodegeneration is ameliorated in NLRP3^−/− or IL-1R1^−/− mice. Representative images of TH immunostaining (a) in SN of WT, NLRP3^−/−, and IL-1R^−/− mice at 10 months after LPS 5 mg/kg or saline i.p injection were shown (n = 3/group). Scale bar = 300 μm. Brain TH-ir neuron number was manually (b) and stereologically (c) counted, respectively, after LPS or vehicle treatment indicated in picture (a). ***p < 0.001 and NS compared with respective saline group. Two-way ANOVA followed by Bonferroni post hoc multiple comparison test