Table 4.
Associations of mtDNA 8-OHdG with coronary stenosis severity as determined by the number of disease vessels and quartiles of modified Gensini scores
| mtDNA 8-OHdG | No. of diseased vessels with > 50% stenosis | OR (95% CI)a | Quartiles of modified Gensini scoresb | OR (95% CI)a | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Non-CAD | 1 | 2 | 3/LMCAD | Q1 | Q2 | Q3 | Q4 | |||
| All participants | ||||||||||
| Each 1-SD increase | 866 | 448 | 337 | 269 | 1.29 (1.19–1.41) | 486 | 478 | 482 | 474 | 1.28 (1.18–1.39) |
| Quartiles, N (%) | ||||||||||
| Q1 | 261 (30.1) | 97 (21.7) | 86 (25.5) | 49 (18.2) | 1 (Reference) | 149 (30.6) | 137 (28.7) | 117 (24.3) | 90 (19.0) | 1 (Reference) |
| Q2 | 251 (29.0) | 108 (24.1) | 59 (17.5) | 57 (21.2) | 0.92 (0.72–1.18) | 132 (27.2) | 130 (27.2) | 116 (24.0) | 97 (20.4) | 1.08 (0.86–1.36) |
| Q3 | 213 (24.6) | 104 (23.2) | 85 (25.2) | 78 (29.0) | 1.33 (1.06–1.69) | 115 (23.7) | 110 (23.0) | 131 (27.2) | 124 (26.2) | 1.42 (1.13–1.78) |
| Q4 | 141 (16.3) | 139 (31.0) | 107 (31.8) | 85 (31.6) | 1.91 (1.50–2.42) | 90 (18.5) | 101 (21.1) | 118 (24.5) | 163 (34.4) | 1.94 (1.54–2.44) |
| P for trend | < 0.001 | < 0.001 | ||||||||
| After PS matching | ||||||||||
| Each 1-SD increase | 673 | 295 | 211 | 167 | 1.36 (1.22–1.50) | 358 | 364 | 288 | 336 | 1.33 (1.21–1.47) |
| Quartiles | ||||||||||
| Q1 | 187 (27.8) | 69 (23.4) | 56 (26.5) | 24 (14.4) | 1 (Reference) | 98 (27.4) | 108 (29.7) | 77 (26.8) | 53 (15.8) | 1 (Reference) |
| Q2 | 190 (28.2) | 71 (24.0) | 38 (18.0) | 39 (23.4) | 0.98 (0.73–1.31) | 95 (26.5) | 103 (28.3) | 66 (22.9) | 74 (22.0) | 1.12 (0.85–1.48) |
| Q3 | 176 (26.2) | 63 (21.4) | 54 (25.6) | 46 (27.5) | 1.27 (0.95–1.70) | 87 (24.3) | 80 (22.0) | 85 (29.5) | 87 (25.9) | 1.49 (1.14–1.96) |
| Q4 | 120 (17.8) | 92 (31.2) | 63 (29.9) | 58 (34.7) | 2.04 (1.53–2.72) | 78 (21.8) | 73 (20.0) | 60 (20.8) | 122 (36.3) | 2.01 (1.52–2.65) |
| P for trend | < 0.001 | |||||||||
PS propensity score, 8-OHdG 8-hydroxy-2′-deoxyguanosine, LMCAD left main coronary artery disease
aModels were adjusted for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, dyslipidemia., FPG, HbA1c, diabetes duration, and type of diabetes management
bThe median (interquartile range) of modified Gensini scores before and after PS matching was 27 (20–36) and 27 (20–35.5), respectively