Table 5.
Associations of mtDNA 8-OHdG with 11 cardiovascular biomarkers in patients with T2DM
| Variables | All participants | After PS matching | ||||
|---|---|---|---|---|---|---|
| N | β (95% CI)a | Pa | N | β (95% CI)a | Pa | |
| Blood lipids | ||||||
| TG (mmol/L) | 1920 | 0.035 (− 0.007, 0.078) | 0.100 | 1346 | 0.046 (− 0.006, 0.098) | 0.081 |
| TC (mmol/L) | 1920 | 0.002 (− 0.044, 0.048) | 0.925 | 1346 | − 0.001 (− 0.057, 0.054) | 0.962 |
| LDL-c (mmol/L) | 1920 | 0.014 (− 0.023, 0.050) | 0.462 | 1346 | − 0.008 (− 0.020, 0.005) | 0.251 |
| HDL-c (mmol/L) | 1920 | − 0.010 (− 0.020, 0.000) | 0.059 | 1346 | 0.011 (− 0.032, 0.053) | 0.498 |
| Blood glucose | ||||||
| FPG (mmol/L) | 1920 | 0.040 (− 0.038, 0.118) | 0.319 | 1346 | 0.001 (− 0.085, 0.087) | 0.987 |
| HbA1c (%) | 1920 | 0.000 (− 0.053, 0.053) | 0.996 | 1346 | − 0.038 (− 0.148, 0.071) | 0.492 |
| Blood pressure | ||||||
| SBP (mmHg) | 1920 | 1.971 (− 0.210, 4.043) | 0.077 | 1346 | 1.297 (− 0.186, 2.780) | 0.086 |
| DBP (mmHg) | 1920 | 0.725 (− 0.124, 1.575) | 0.094 | 1346 | 0.718 (− 0.277, 1.714) | 0.157 |
| Inflammation | ||||||
| CRP (mg/L) | 1920 | 0.182 (0.055, 0.309) | 0.005 | 1346 | 0.172 (0.028, 0.315) | 0.019 |
| D-dimer (mg/L) | 1798 | − 0.019 (− 0.067, 0.028) | 0.431 | 1258 | 0.000 (− 0.057, 0.055) | 0.980 |
| Adiposity | ||||||
| BMI (m/kg2) | 1920 | 0.068 (− 0.016, 0.153) | 0.111 | 1346 | 0.045 (− 0.162, − 0.252) | 0.670 |
Italic values indicate significant results with P < 0.05
BMI body mass index, FPG fasting plasma glucose, HbA1c glycosylated haemoglobin, TC total cholesterol, LDL-c low-density lipoprotein cholesterol, HDL-c high-density lipoprotein cholesterol, TG triglycerides, SBP systolic blood pressure, DBP diastolic blood pressure, CRP C-reactive protein
aMultivariable linear regression was performed with the mtDNA 8-OHdG as the independent variable and each cardiovascular biomarker as the dependent variable, with adjustment for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, dyslipidemia., diabetes duration, and type of diabetes management