Table 6.
Associations of continuous and dichotomous mtDNA 8-OHdG with 1-year outcomes after coronary revascularization
| Outcomes | Continuous mtDNA 8-OHdG | Dichotomous mtDNA 8-OHdG | ||||
|---|---|---|---|---|---|---|
| HR (95%CI)a | Pa | No. of eventsb | HR (95%CI)a | Pa | ||
| High (n = 344) | Low (n = 357) | |||||
| MACCE | 1.59 (1.33–1.90) | < 0.001 | 78 (22.7) | 31 (8.7) | 2.74 (1.80–4.17) | < 0.001 |
| All-cause death | 2.06 (1.59–2.66) | < 0.001 | 34 (9.9) | 11 (3.1) | 3.36 (1.69–6.69) | < 0.001 |
| Cardiac death | 1.92 (1.33–2.78) | < 0.001 | 19 (5.5) | 5 (1.4) | 3.80 (1.40–10.3) | 0.009 |
| Repeat revascularization | 1.26 (0.98–1.62) | 0.078 | 47 (13.7) | 19 (5.3) | 2.67 (1.55–4.57) | < 0.001 |
| Non-fatal MI | 1.42 (0.91–2.22) | 0.126 | 12 (3.5) | 7 (2.0) | 2.30 (0.89–5.92) | 0.085 |
| Non-fatal stroke | 1.45 (0.59–3.58) | 0.417 | 3 (0.9) | 2 (0.6) | 1.71 (0.27–10.8) | 0.569 |
MACCE major adverse cardiovascular and cerebral events, MI myocardial infarction
aModels were adjusted for age, sex, smoking habit, alcohol drinking habit, overweight/obesity, hypertension, dyslipidemia., FPG, HbA1c, diabetes duration, and type of diabetes management
bThe cutoff that categorized the value of mtDNA 8-OHdG as high or low was 3.22 ∆ct based on the results of time-dependent ROC