Table 1.
Demographic information for the final cohort who passed imaging quality control process
| Overall (N = 137) | Normal cognition | MCI | AD | |||||
|---|---|---|---|---|---|---|---|---|
| Caucasian (n = 72) | African American (n = 65) | Caucasian (n = 31) | African American (n = 27) | Caucasian (n = 25) | African American (n = 28) | Caucasian (n = 16) | African American (n = 10) | |
| Age, years (SD) | 70.90 (7.84) | 69.20 (7.49) | 71.65 (8.39)* | 67.48 (6.17)* | 71.52 (5.82) | 70.07 (7.74) | 68.50 (9.41) | 71.4 (9.65) |
| Women (Men) | 35 (37) | 43 (29) | 19 (12) | 17 (10) | 15 (10) | 12 (16) | 9 (7) | 6 (4) |
| Years of Education (SD) | 16.32 (2.85) | 16.15 (2.85) | 16.81 (2.69) | 15.78 (2.66) | 17.08 (2.58) | 16.29 (2.81) | 14.19 (1.94) | 16.80 (3.55) |
| MMSE (SD) | 26.32 (4.90) | 26.91 (3.57) | 28.84 (0.86) | 28.00 (1.86) | 27.64 (1.68) | 26.67 (2.34) | 21.37 (3.38) | 20.22 (6.18) |
| Cognitive Z Scores (SD) | −0.78 (1.12) | −0.72 (0.99) | 0.07 (0.51) | −0.11 (0.51) | − 0.88 (0.86) | − 0.67 (0.59) | −2.24 (0.66) | −2.36 (1.02) |
| White Matter Hyperintensity volume (mm3) | 3984.40 (4110.10) | 3886.03 (4964.93) | 3306.81 (3337.32) | 2440.93 (2576.15) | 4018.66 (4080.03) | 4313.70 (5330.60) | 5243.68 (5333.14) | 6730.21 (7607.48) |
| Having ABCA7 risk allele, (%) | 23.67* | 43.10* | 29.00 | 44.40 | 24.00 | 50.00 | 12.50 | 30.00 |
| Have Diabetes, (%) | 5.67** | 33.80** | 6.50** | 33.33** | 0* | 28.60* | 12.50* | 50.00* |
| Have Hypertension (%) | 45.83** | 72.31** | 45.16 | 62.96 | 56.00 | 78.57 | 31.25* | 80.00* |
| CSF Aβ42, pg/ml (SD) | 148.35 (95.02) | 168.48 (128.86) | 199.93 (132.30) | 165.27 (89.8) | 199.11 (141.02) | 134.69 (90.99) | 77.65 (47.39) | 133.55 (140.71) |
| CSF t-Tau, pg/ml (SD) | 72.84 (49.63)** | 40.92 (20.79)** | 51.68 (30.96)** | 36.04 (11.63)** | 63.99 (33.71)* | 35.44 (13.67)* | 108.48 (77.43) | 75.8 (33.52) |
| CSF p-Tau181, pg/ml (SD) | 17.58 (8.97)** | 25.81 (12.47)** | 23.47 (9.71)** | 14.05 (5.07)** | 25.01 (13.42)* | 17.74 (7.21)* | 33.53 (14.64) | 24.54 (10.27) |
| CSF t-Tau/Aβ42 | 0.73 (0.91)* | 0.24 (0.22)* | 0.46 (0.74)* | 0.15 (0.12)* | 0.44 (0.42)* | 0.22 (0.14)* | 1.36 (1.16) |
0.55 (0.41) |
Note: T-tests were performed to compare races in the whole cohort and within each diagnostic category. *p < .05, **p < .001. MMSE and CogZ scores were significantly different between diagnostic categories such, NC having highest MMSE scores and AD having lowest (MMSE: NC vs MCI, p = .007, MCI vs AD, p < .0001, CogZ: NC vs MCI, p < .0001, MCI vs AD, p < .0001)