Table 5.
Factors differentially associated with AD biomarkers according to race (unadjusted p ≤ 0.01), adjusting for age, gender, mean framewise displacement, and APOE ε4 allele
| Subsystem | Connectivity Pair | Variable Name | B(95% Confidence Interval) | Unadjusted p | Storey’s q |
|---|---|---|---|---|---|
| Dorsomedial to midline core | Dorsomedial Prefrontal Cortex to Precuneus | Race | −0.02(−0.30, 0.25) | 0.861 | |
| Cognitive impairment | 0.04(−0.13, 0.04) | 0.292 | |||
| Race * Cognitive impairment | −0.14(0.07, 0.25) | 0.005 | 0.092 | ||
| Ventrolateral Temporal Cortex to Precuneus | Race | −0.24(− 0.59, 0.11) | 0.170 | ||
| Cognitive impairment | −0.08(− 0.02, 0.19) | 0.103 | |||
| Race * Cognitive impairment | 0.18(0.02, 0.17) | 0.001 | 0.055 | ||
| Race | −0.05(−0.32, 0.21) | 0.695 | |||
| t-Tau | −0.003(− 0.02, − 0.002) | 0.712 | |||
| Race * t-Tau | 0.02(−0.03, − 0.0002) | 0.001 | 0.055 | ||
| Dorsomedial Prefrontal cortex to Posterior Cingulate Cortex | Race | 0.29(0.08, 0.50) | 0.007 | ||
| Cognitive Impairment | 0.05(−0.15, 0.03) | 0.407 | |||
| Race * Cognitive impairment | 0.18(0.02, 0.17) | 0.007 | 0.096 | ||
| Temporal Pole to Precuneus | Race | 0.05(−0.18, −0.29) | 0.667 | ||
| Aβ42 | 0.0003(0.00, 0.01) | 0.345 | |||
| Race * Aβ42 | −0.001(−0.002, − 0.00001) | 0.004 | 0.073 | ||
| Race | −0.80(− 0.29, 0.13) | 0.442 | |||
| t-Tau | −0.002(− 0.01, − 0.001) | 0.736 | |||
| Race * t-Tau | 0.003(0.001, 0.006) | 0.005 | 0.069 | ||
| Dorsolateral Temporal Cortex to Precuneus | Race | −0.21(−0.12, 0.36) | 0.112 | ||
| Aβ42 | 0.0002(−0.0001, 0.01) | 0.345 | |||
| Race * Aβ42 | −0.002(− 0.003, − 0.00001) | 0.002 | 0.055 | ||
| Race | −0.21(− 0.43, 0.02) | 0.070 | |||
| t-Tau | −0.001(− 0.002, − 0.02) | 0.066 | |||
| Race * t-Tau | 0.004(0.001, 0.006) | 0.003 | 0.083 | ||
| Race | −0.074(− 0.20,0.54) | 0.004 | |||
| Cognitive impairment | 0.27(−0.04,0.09) | 0.001 | |||
| Race * Cognitive impairment | 0.20(0.05, 0.25) | 0.002 | 0.055 | ||
| MTL to midline core | Posterior Cingulate to Hippocampus | Race | −0.001(−0.22, 0.22) | 0.900 | |
| t-Tau | −0.001(− 0.03, 0.002) | 0.199 | |||
| Race * t-Tau | 0.003(0.001, 0.052) | 0.004 | 0.073 |
Unadjusted p-values which remain significant after Benjamini-Hochberg step-up correction for multiple comparisons are bolded. Storey’s q-values are also shown with FDR < 10%. MTL Medial Temporal Lobe, IPL inferior parietal lobule