Fig. 3.

Clinical characteristics of the 5 trajectory classes of the 5-class LCMM. a Each class’ spaghetti-plot of the 5-class LCMM with the modeled trajectory estimated using B-splines. Time 0 was defined by the date of the baseline mRSS record. mRSS: modified Rodnan skin score. b Graphs representing the autoantibodies in each class. ACA: anti-centromere antibodies; RNAP3: anti-RNA polymerase III antibodies; ATA: anti-topoisomerase I antibodies; others: no specific SSc target antibodies. c Graphs illustrating the main organ involvement in each class. DU: digital ulcers; GIT: gastrointestinal tracts; ILD: interstitial lung disease; PH: pulmonary hypertension; SRC: scleroderma renal crisis