Fig. 1.

Reduced ADAMTS13 activity and increased VWF levels in the plasma of EAE mice. Plasma was obtained from naïve and EAE mice at different times. a Relative ADAMTS13 activities from EAE and naïve mice are shown. b VWF levels from the plasma of naïve and EAE mice are shown by western blot. The results are expressed as the mean ± SEM (n = 6). Statistical significance was determined by one-way ANOVA followed by Dunnett’s posttest. *P < 0.05; **P < 0.01. dpi day post immunization, LMW low molecular weight VWF, UL ultra large VWF