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The IL-6 pathway is overexpressed in IPF-HLFs. RNA and proteins were extracted from IPF (n = 8) and control donor lung tissue lysates (n = 8) a-d, as well as from human lung fibroblasts (HLF) derived from patients with IPF (n = 10) or control donors (n = 14) (N) e-h. IL-6R mRNA was measured by qPCR a,e. pSTAT3-Y705 c,g and SOCS3 protein (D,H) levels were measured by western blotting. b,f Representative western blots for Figs. c-d and g-h. *p < 0.05, **p < 0.01, and ***p < 0.001 (n ≥ 4)
