Table 1.
Putative proteases assigned by MEROPS and the web servers PROSPER and iProt-Sub to produce the amino termini and carboxyl termini of the identified truncated forms. *
| Assigned Proteases | Number of truncated proteoforms cleaved |
|
|---|---|---|
| Amino termini | Carboxyl termini | |
| calpain-1 | 10 | 6 |
| calpain-2 | 0 | 1 |
| cathepsin B | 0 | 4 |
| cathepsin D | 26 | 5 |
| cathepsin E | 28 | 11 |
| cathepsin G | 273 | 83 |
| cathepsin K | 15 | 20 |
| cathepsin L | 24 | 10 |
| cathepsin S | 8 | 4 |
| cathepsin Z | 0 | 22 |
| coagulation factor X | 46 | 35 |
| dipeptidyl peptidase 1 | 1 | 0 |
| elastase-2 | 67 | 101 |
| legumain | 2 | 31 |
| matriptase-3 | 0 | 1 |
| Meprin A subunit alpha | 0 | 1 |
| Methionine aminopeptidase-1 and -2 | 171 | 0 |
| MMP2 | 39 | 20 |
| MMP3 | 10 | 30 |
| MMP7 | 1 | 0 |
| MMP9 | 60 | 47 |
| Myeloblastin | 306 | 355 |
| plasmin | 92 | 61 |
| thrombin | 33 | 36 |
| tripeptidyl-peptidase-1 and -2 | 24 | 0 |
*
In some cases, more than one protease could be responsible for the production of a truncated form. Previously identified proteases in MDSC and MDSC-derived extracellular vesicles are shown in italics.