. 2020 Jan 31;7(2):ofaa035. doi: 10.1093/ofid/ofaa035

Table 1.

Demographic Data and Clinical Presentations Among IVCY and RTX Groups

			IVCY Group
			Microorganisms		Clinical Manifestations and Organ Involvements
Case No.	Gender	Age at Disease Onset, y	NTM	Other	Prolonged Fever	Weight Loss	Lymphadenopathy	Skin	Pulmonary	Septicemia	Musculoskeletal	Miscellaneous	Duration From Disease Onset to IGA Diagnosis, d	Duration From Disease Onset to Enrollment, d	Prior Treatment	Cumulative Dose of IVCY/ Cycles, mg	Outcome of Treatment
1	F	35	M. avium complex, M. fortuitum	None	X	X	X	X	X	X	X		39	1926	ABx + IVCY (NIH regimen) × 7 cycles	11 250/13	R
2	M	59	M. kansasii	Salmonella spp., HSV, Cryptococcus spp.	X	X	X	X	X	X	X	X	882	1747	ABx + plasmaphe- resis × 3 d	7500/10	R
3	F	56	NTM	None	X	X	X	X					81	540	ABx	4100/8	R
4	M	59	M. abscessus	HZV	X	X	X	X	X			X	21	1086	ABx	4600/6	R
5	M	40	M. abscessus	None	X	X	X				X		571	1600	ABx	7400/10	R
6	F	47	M. manteneii	Cryptococcus spp.	X	X	X	X	X	X	X		158	907	ABx	3350/6	PR
7	F	45	M. parascofula- ceum, M. abscessus	None	X	X	X	X	X	X		X	53	835	ABx + IVCY (NIH regimen) × 6 cycles	3650/5	PR
8	M	62	M. abscessus	Salmonella spp., HSV, Cryptococcus spp.	X	X	X	X	X	X			29	163	ABx	2800/5	R
9	M	46	M. abscessus	None	X	X	X	X			X	X	59	659	ABx	6050/7	R
10	M	52	M. abscessus	Cryptococcus spp., cytomegalovirus	X	X	X	X	X	X		X	252	488	ABx	4700/6	R
11	M	64	M. fortuitum	Salmonella spp.	X	X	X	X	X	X			36	213	ABx	3900/6	R
			RTX Group
Case No.	Gender	Age at Disease Onset, y	Microorganisms		Clinical Manifestations and Organ Involvements								Duration From Disease Onset to IGA Diagnosis, d	Duration From Disease Onset to Enrollment, d	Prior Treatment	Cumulative Dose of RTX/Cycles, mg/m²	Outcome of Treatment
Case No.	Gender	Age at Disease Onset, y	NTM	Other	Prolonged Fever	Weight Loss	Lymphadenopathy	Skin	Pulmonary	Septicemia	Musculoskeletal	Miscellaneous	Duration From Disease Onset to IGA Diagnosis, d	Duration From Disease Onset to Enrollment, d	Prior Treatment	Cumulative Dose of RTX/Cycles, mg/m²	Outcome of Treatment
1	F	66	None	Salmonella spp., HSV, HZV	X	X		X		X			108	250	ABx	345/6	PR
2	F	48	M. avium complex	None	X	X	X		X				1275	1997	ABx	339/4	R
3	F	44	M. szulgai, M. angelicum	MTB	X	X	X		X		X		128	231	ABx	359//4	PR
4	F	79	M. avium complex	None				X					180	383	ABx	326/2	R
5	M	51	M. avium complex	None									279	574	ABx	319/2	R
6	M	62	None	Salmonella spp.	X			X	X	X		X	174	876	ABx	286/2	R

Abbreviations: ABx, antibiotics; F, female; HSV, herpes simplex virus; HZV, herpes zoster virus; IGA, adult-onset immunodeficiency associated with interferon-γ autoantibody; IVCY, intravenous cyclophosphamide; M, male; MKD, mg/kg/dose; MTB, M. tuberculosis; NIH, National Institutes of Health; NTM, nontuberculous mycobacteria; PR, partial remission; R, remission; RTX, rituximab.