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. 2019 Apr 30;30(1):256–268. doi: 10.1093/cercor/bhz085

Figure 2.

Figure 2

Precocious maturation of PNNs enwrapping PV cells in Mecp2 KO mice. (A) Double immunostaining of PNNs with WFA (red) and PV (green) in immature (P15) and mature visual cortex (P60) of Mecp2 WT and KO mice. Scale bar: 50 μm. (B) PNN cell density, measured as WFA-positive structures, is increased in Mecp2 KO mice. (C) Percentage of PV cells enwrapped by WFA is also increased in Mecp2 KO mice. n = 5–6 animals per age and genotype. Two-way ANOVA, *P < 0.05; **P < 0.01; ***P < 0.001, Bonferroni’s post-test. Mean ± s.e.m.