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. 2019 Apr 30;30(1):256–268. doi: 10.1093/cercor/bhz085

Figure 4.

Figure 4

Mecp2 deletion in PV cells promotes the formation of PNNs around PV cells. (A) Triple staining for WFA (red), PV (green), and MeCP2 (cyan) in the visual cortex of Mecp2+/y/PV-Cre Het (c-WT) and Mecp2lox/y/PV-Cre Het (c-KO) at P200. (B) Selective deletion of Mecp2 in WFA-positive cells. (C, D) PV (C) and WFA (D) immunofluorescent mean intensity are upregulated in c-KO compared to c-WT littermates. (D) Percentage of PV-positive cells enwrapped by WFA is increased in c-KO compared to c-WT. Scale bar: 100 μm (A); 50 μm (B). n = 3 animals per genotype. Mann–Whitney test, *P < 0.05; **P < 0.01; ***P < 0.001. Mean ± s.e.m.