Table 1.
Maternal and fetal demographics of fetuses with Down syndrome and typically developing controls
| Subject | Ethnicity | Maternal age | Maternal risks* | CVS/AC/postnatal karyotype | Fetal sex |
GA of MRI
[weeks] |
Other anomalies | |
|---|---|---|---|---|---|---|---|---|
| Down syndrome | DS-01 | White | 30 | None | 47,XX,+21 | F | 30.86 | None |
| DS-02 | White | 33 | None | 47,XY,+21 | M | 31.57 | None | |
| DS-03 | White | 30 | None | 47,XX,+21 | F | 29.71 | AVCD repaired after birth | |
| DS-07 | White | 41 | None | 47,XX,+21 | F | 30.00 | AVCD repaired after birth | |
| DS-08 | White | 33 | None | 47,XX,+21 | F | 22.29 & 29.71 | ASD, mitral regurgitation, PFO repaired after birth | |
| DS-10 | White | 36 | None | 47,XY,+21 | M | 21.71 | Neonatal pulmonary hypertension | |
| DS-11 | White | 34 | None | 47,XX,+21 | F | 35.14 | None | |
| DS-13 | White | 44 | None | 47,XY,+21 | M | 27.43 | Interrupted aortic arch repaired after birth, hydronephrosis | |
| BDS-02 | White | 38 | Cymbalta, Lyrica for fibromyalgia | 47,XY,+21 | M | 32.43 | Tricuspid regurgitation | |
| Typically Developing Controls | BM-10 | White | 23 | None | N/A | M | 20 | None |
| BM-18 | White | 30 | None | N/A | M | 29.57 | None | |
| BM-26 | White | 31 | None | N/A | M | 18.57 | None | |
| BM-28 | White | 32 | None | N/A | F | 22.86 | None | |
| BM-37 | Asian | 22 | None | N/A | F | 29.14 | None | |
| BM-38 | Asian | 33 | None | N/A | F | 25.57 | None | |
| BM-39 | White | 34 | None | N/A | M | 32 | None | |
| BM-42 | White | 30 | None | N/A | M | 33.29 | None | |
| BM-47 | White | 34 | None | N/A | M | 24.71 | None | |
| BM-54 | White | 27 | None | N/A | M | 19.71 | None | |
| BM-92 | African American | 22 | None | N/A | F | 20.86 | None | |
| BM-97 | White | 31 | None | N/A | M | 25.71 | None |
Note: In visual assessment, no cerebral ventriculomegaly nor apparent cerebellar hypoplasia was appreciated. AC: amniocentesis, ASD: atrial septal defect, AVCD: atrioventricular canal defect, CVS: chorionic villi sampling, GA: gestational age, PFO: patent foramen ovale. *Maternal risks: gestational hypertension, diabetes, medications, smoking, alcohol, or recreational drug consumption.