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. 2019 Apr 30;30(1):148–164. doi: 10.1093/cercor/bhz078

Figure 4.

Figure 4

Distribution of dopamine receptors in pyramidal neuron populations across cortical layers. (A) The proportion of D1R-expressing neurogranin+ pyramidal neurons is larger than the proportion of D2R-expressing neurogranin+ neurons across all layers. This difference was statistically significant in layers II–V. Overall, the ratio of D1Rs to D2Rs decreases across cortical layers (right y-axis). (B) The proportion of D1R-expressing SMI-32+ pyramidal neurons is also larger than the proportion of D2R-expressing SMI-32+ neurons across all layers. This difference was statistically significant in layers II-III, and VI. *, **, and *** denote significance at the level of 0.05, 0.01, and 0.001 after Bonferroni correction. Significance was determined using chi-squared tests calculated on total counts. Neurogranin+ N = 766, 111, 262, 575; P < 10−16, 0.0048, 9.39 × 10−8, 1.6 × 10−4 for layers II-III, IV, V, and VI, respectively. SMI-32+ N = 72, 31, 35, 73; P = 0.0023, 0.2, 0.09, and 0.0019 for layers II-III, IV, V, and VI respectively. Bar heights and standard error bars are calculated from the across-animal mean proportions and the exact values are described in Table 4. Animal Ns respectively for Neurogranin+ D1R, D2R = 4, 4; SMI-32+ D1R, D2R = 3, 4.