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. 2019 Apr 30;30(1):148–164. doi: 10.1093/cercor/bhz078

Figure 7.

Figure 7

Distribution of dopamine receptors across inhibitory neuron populations across cortical layers. (A) Across all layers, the proportion of D2R-expressing parvalbumin+ neurons is higher than the proportion of D1R-expressing parvalbumin+ neurons. (B) There is no significant difference in the relative prevalence of D1Rs compared with D2Rs in calbindin+ neurons across layers. (C) There is no significant difference in the relative prevalence of D1Rs compared with D2Rs in calretinin+ neurons across layers. Significance was determined using chi-squared tests calculated on total counts. Parvalbumin+ N = 197, 44, 88, 75; P = 1.98 × 10−7, 3.89 × 10−5, 1.36 × 10−10, 4.65 × 10−9 for layers II, III, IV, V, and VI, respectively. Calbindin+ N = 232, 34, 46, 70; P = 0.64, 0.46, 0.61, 0.31 for layers II, III, IV, V, and VI, respectively. Calretinin+ N = 352, 31, 41, 52; P = 5.04 × 10−4, 0.42, 0.87, and 0.27 for layers II, III, IV, V, and VI, respectively. Bar heights and standard error bars are calculated from the across-animal mean proportions and the exact values are described in Table 4. Animal Ns respectively for Parvalbumin+ D1R, D2R = 4, 3; Calbindin+ D1R, D2R = 4, 4; Calretinin+ D1R, D2R = 3, 4.