Table 4.
Effects of birth weight and HF on hippocampal metabolism as determined by single-voxel spectroscopy in 4 week-old pigletsa.
| Treatment | Pooled SEM | P-Valueb | ||||||
|---|---|---|---|---|---|---|---|---|
| Metabolite | AGA CON | AGA HF | SGA CON | SGA HF | Size | Diet | Size*Diet | |
| Asp | 2.678 | 2.728 | 2.688 | 2.840 | 0.243 | 0.620 | 0.417 | 0.679 |
| GSH | 2.181 | 2.330 | 2.286 | 2.380 | 0.215 | 0.474 | 0.267 | 0.803 |
| Ins | 7.094 | 7.322 | 7.120 | 7.344 | 0.261 | 0.855 | 0.093 | 0.990 |
| Scyllo | 0.379 | 0.379 | 0.374 | 0.337 | 0.033 | 0.173 | 0.275 | 0.263 |
| GPC + PCh | 1.765 | 1.814 | 1.689 | 1.746 | 0.106 | 0.156 | 0.288 | 0.939 |
| NAA + NAAG | 5.755 | 5.835 | 5.745 | 6.027 | 0.280 | 0.521 | 0.204 | 0.474 |
| Cr + PCr | 4.673 | 4.720 | 4.630 | 4.659 | 0.169 | 0.544 | 0.657 | 0.916 |
| Glu + Gln | 8.368 | 9.095 | 8.394 | 8.662 | 0.645 | 0.533 | 0.134 | 0.482 |
| MM14 + Lip13a + Lip13b + MM12 | 10.970 | 8.716 | 8.196 | 9.195 | 1.206 | 0.068 | 0.307 | 0.012 |
| MM09 + Lip09 | 5.185 | 4.646 | 3.943 | 4.435 | 0.555 | 0.014 | 0.933 | 0.073 |
| MM20 + Lip20 | 8.972 | 9.718 | 8.432 | 8.868 | 0.815 | 0.099 | 0.157 | 0.706 |
Values are means of 6–9 replicate pigs with MRI data collected at 26–29 d of age. AGA CON n = 8, n = 7 (MM14 + Lip13a + Lip13b + MM12); AGA HF n = 8, n = 7 (Scyllo), n = 6 (Asp); SGA CON n =8, n = 7 (Asp, Scyllo, MM14 + Lip13a + Lip13b + MM12); SGA HF n = 9. Bold values are significance.
Size, main effect of birth weight (i.e., AGA vs. SGA); Diet, main effect of dietary intervention (i.e., HF vs. CON); Size*Diet, interaction effect of birth weight, and dietary intervention.
Data presented as means and pooled SEM.
AGA, appropriate for gestational age; SGA, small for gestational age; CON, control; HF, hydrolyzed fat; NAA + NAAG, N-acetylaspartate + N-acetylaspartylglutamate; GPC + PCh, glycerophosphocholine + phosphocholine; Cr + PCr, creatine + phosphocreatine; Glu + Gln, glutamate + glutamine; MM, macromolecule; Lip, lipid.