Table 7.
Pathway analysis of select up-regulated genes due to SGA in the hippocampus of 2 week-old pigletsa.
| Top enriched KEGG pathways | Enrichment score | Gene count | P-Value | Benjamini valueb |
|---|---|---|---|---|
| cAMP signaling pathway | 1.89 | 8 | 8.20E-03 | 9.10E-02 |
| Calcium signaling pathway | 1.64 | 9 | 1.10E-03 | 2.70E-02 |
| Circadian entrainment | 1.64 | 7 | 1.40E-03 | 2.90E-02 |
| Olfactory transduction | 1.64 | 4 | 2.40E-03 | 4.00E-02 |
| Oxytocin signaling pathway | 1.64 | 8 | 3.70E-03 | 5.40E-02 |
| Amphetamine addiction | 1.64 | 5 | 8.10E-03 | 9.60E-02 |
| Long-term potentiation | 1.64 | 5 | 8.60E-03 | 8.80E-02 |
| Cholinergic synapse | 1.64 | 6 | 1.30E-02 | 1.20E-01 |
| Dopaminergic synapse | 1.64 | 6 | 1.70E-02 | 1.40E-01 |
| Inflammatory mediator regulation of TRP channels | 1.64 | 5 | 2.90E-02 | 2.00E-01 |
| Retrograde endocannabinoid signaling | 1.64 | 5 | 3.30E-02 | 2.10E-01 |
| Glioma | 1.64 | 4 | 4.10E-02 | 2.40E-01 |
| Glutamatergic synapse | 1.64 | 5 | 6.40E-02 | 3.00E-01 |
| Wnt signaling pathway | 1.64 | 5 | 7.00E-02 | 3.10E-01 |
| GnRH signaling pathway | 1.64 | 4 | 8.70E-02 | 3.60E-01 |
| Neurotrophin signaling pathway | 1.64 | 4 | 1.90E-01 | 5.60E-01 |
| GABAergic synapse | 1.64 | 3 | 2.70E-01 | 6.70E-01 |
| ErbB signaling pathway | 1.64 | 3 | 3.00E-01 | 6.90E-01 |
| Morphine addiction | 1.64 | 3 | 3.00E-01 | 6.90E-01 |
| HIF-1 signaling pathway | 1.64 | 3 | 3.50E-01 | 7.40E-01 |
| Serotonergic synapse | 1.64 | 3 | 3.70E-01 | 7.50E-01 |
a
Enrichment scores as determined by Functional Annotation Clustering in DAVID v.6.8, which rank overall importance of the annotation term groups. The most relevant 22 are displayed, see Supplementary Table S1 for complete list. AGA CON n = 6, AGA HF n = 6, SGA CON n = 6, SGA HF n = 6.
b
Main effect of birth weight (i.e., SGA vs. AGA); the Benjamini value corrects for multiple comparisons.
AGA, appropriate for gestational age; SGA, small for gestational age.