Table 8.
Pathway analysis of down-regulated genes due to HF diet in the hippocampus of 2 week-old pigletsa.
| Top enriched KEGG pathways | Enrichment score | Gene count | P-Value | Benjamini valueb |
|---|---|---|---|---|
| Herpes simplex infection | 2.3 | 6 | 4.40E-06 | 2.90E-04 |
| Viral myocarditis | 2.3 | 4 | 1.00E-04 | 3.40E-03 |
| Graft-versus-host disease | 2.3 | 3 | 7.10E-04 | 1.60E-02 |
| Allograft rejection | 2.3 | 3 | 8.60E-04 | 1.40E-02 |
| Autoimmune thyroid disease | 2.3 | 3 | 9.40E-04 | 1.20E-02 |
| Type I diabetes mellitus | 2.3 | 3 | 1.20E-03 | 1.30E-02 |
| Antigen processing and presentation | 2.3 | 3 | 4.60E-03 | 4.30E-02 |
| HTLV-1 infection | 2.3 | 4 | 7.90E-03 | 6.40E-02 |
| Cell adhesion molecules (CAMs) | 2.3 | 3 | 1.80E-02 | 1.30E-01 |
| Phagosome | 2.3 | 3 | 2.30E-02 | 1.50E-01 |
a
Enrichment scores as determined by Functional Annotation Clustering in DAVID v.6.8, which rank overall importance of the annotation term groups. AGA CON n = 6, AGA HF n = 6, SGA CON n = 6, SGA HF n = 6.
b
Main effect of diet (i.e., CON vs. HF); the Benjamini value corrects for multiple comparisons.
CON, control; HF, hydrolyzed fat.