Table 1. Cannabidiol (CBD) stability experiments under various storage conditions.

Experiment	Temperature (°C)	Light exposure	Storage time	Storage medium	CBD concentration in medium (μg/L)	Δ 9-THC formation 1
Negative control	-18	None	14 days	Methanol	1000	0%
Light	20	None	3 days	Methanol	1000	0%
	20	None	14 days	Methanol	1000	0%
	20	Daylight	3 days	Methanol	1000	0%
	20	Daylight	14 days	Methanol	1000	0%
	20	UVA	1 h	Methanol	1000	0%
	20	UVA	3 h	Methanol	1000	0%
Temperature	20	None	5 days	Methanol	1000	0%
	20	None	14 days	Methanol	1000	0%
	8	None	5 days	Methanol	1000	0%
	8	None	14 days	Methanol	1000	0%
	37	None	3 h	Methanol	1000	0%
	60	None	1 h	Methanol	1000	0%
Simulated gastric juice	37	None	1 h	Simulated gastric juice	200	0%
	37	None	2 h	Simulated gastric juice	200	0%
	37	None	3 h	Simulated gastric juice	200	0%
	37	None	1 h	Simulated gastric juice	400	0%
	37	None	2 h	Simulated gastric juice	400	0%
	37	None	3 h	Simulated gastric juice	400	0%
Positive control	20	None	14 days	Methanol / 1 mol/L HCl (50:50)	500	27%

¹ Average of LC-MS/MS and UPLC-QTOF measurements (n=2) (for raw results see dataset ³¹ , table sheet 1). Δ ⁹-THC formation calculated as % in relation to original CBD content.

Abbreviations: CBD: cannabidiol; Δ ⁹-THC: Δ ⁹-tetrahydrocannabinol; UVA: ultraviolet A; LC-MS/MS: liquid chromatography/tandem mass spectrometry; UPLC-QTOF: ultra-high pressure liquid chromatography/quadrupole time-of-flight mass spectrometry