Figure 3. Vasopressor Use During the First 10 Days of the Trial.

Use of vasopressors was defined as any use of norepinephrine, epinephrine, vasopressin, metaraminol, dopamine, or phenylephrine. Data on doses of vasopressors were obtained every 6 hours, and the 4 doses per day were summed for the vasopressor dose on that study day. Total vasopressor doses was calculated as the sum of norepinephrine doses and converted doses of epinephrine and vasopressin. Patients receiving metaraminol monotherapy did not contribute to total vasopressor dose data, and no patients received dopamine or phenylephrine. Box center lines are medians, box tops and bottoms are interquartile ranges, and error bars are ranges. The trajectory curves connect the daily medians.