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. 2020 Jan 8;161(2):bqaa002. doi: 10.1210/endocr/bqaa002

Figure 3.

Figure 3.

Conditional inhibition of pituitary retinoic acid (RA) signaling causes pituitary dysmorphology after e13.5. A and B, Hesx1Cre/+; R26dnRAR/dnRAR embryos at e11.5 and e13.5 show normal histology and PROP1 expression (e11.5: n = 3 and 3. e13.5: n = 2 and 2). C, Hesx1Cre/+; R26dnRAR/dnRAR embryos exhibit pituitary dysmorphology of the anterior and intermediate lobes at e15.5 (arrowheads), extending ventrally around the infundibulum/posterior lobe (P) (n = 3 and 3). Pituitary dysmorphology persists at P4, showing intermediate lobe dysmorphology around the posterior lobe (arrows) but normal anterior pituitary parenchyma (n = 2 and 3). Scale bars = 100 μm.