Table 3.

Supplementation with 30 mg/kg BW/day XN or its derivatives DXN and TXN decreases the fecal microbial diversity^b

	CON	XN	DXN	TXN	SEM	XN vs CON	DXN vs CON	TXN vs CON
	Microbial Diversity ASV Number (Mice n with counts)					P-values (Comparisons)
Total	399	362	323	318	9	0.004	<0.001	<0.001
Firmicutes	292	258	218	213	9	0.01	<0.001	<0.001
Lachnospiraceae	161	142	121	119	4	0.003	<0.001	<0.001
Ruminococcaceae	66	60	37	36	2.0	0.04	<0.001	<0.001
Erysipelotrichaceae	39	37	46	46	2.9	0.60	0.10	0.11
Eubacteriaceae	4.3 (12)	2.8 (12)	1.4 (12)	1.6 (10)	0.2	<0.001	<0.001	<0.001
Peptostreptococcaceae	3.7 (12)	2.8 (11)	2.1 (10)	1.0 (6)	0.4	0.17	0.01	<0.001
Clostridiaceae	1.2 (12)	0.3 (4)	0.25 (3)	0.09 (1)	0.1	<0.001	<0.001	<0.001
Halobacteroidacea	1.0 (12)	1.0 (12)	0.08 (1)	0 (0)	0.04	1	<0.001	<0.001
Lactobacillaceae	1.0 (11)	0.7 (8)	0.4 (5)	0.7 (8)	0.1	0.09	0.005	0.18
Paenibacillaceae	0.1 (1)	0.5 (6)	0.8 (9)	0.8 (9)	0.1	0.02	<0.001	<0.001
Natranaerovirga	0.1 (1)	0 (0)	1.6 (11)	0.4 (2)	0.2	0.80	<0.001	0.40
Enterococcaceae	0.8 (9)	0.7 (8)	0.2 (2)	0.7 (8)	0.1	0.65	0.003	0.90
Staphylococcaceae	0.7 (8)	0.6 (7)	0.6 (7)	0.4 (4)	0.1	0.69	0.69	0.16
Bacillaceae	0.6 (6)	0.8 (7)	0.8 (7)	0.6 (6)	0.2	0.61	0.45	0.87
Bacteroidetes	67.4	54.6	18.9	12.4	2.6	<0.001	<0.001	<0.001
Porphyromonadaceae	64.0	51.1	15.3	9.3	2.4	<0.001	<0.001	<0.001
Flavobacteriaceae	1.7 (10)	1.8 (11)	2.0 (12)	1.6 (10)	0.3	0.85	0.44	0.95
Chitinophagaceae	0.8 (9)	0.9 (9)	1.3 (10)	1.0 (6)	0.2	0.80	0.22	0.63
Rikenellaceae	0.8 (10)	0.8 (9)	0.4 (5)	0.3 (3)	0.1	0.66	0.03	0.005
Verrucomicrobia	7.1	4.8	7.6	7.6	2.0	0.40	0.86	0.84
Verrucomicrobiaceae	7.1	4.8	7.6	7.6	2.0	0.40	0.86	0.84
Tenericutes	1 (12)	0 (0)	0 (0)	0 (0)	0	<0.001	<0.001	<0.001
Anaeroplasmataceae	1 (12)	0 (0)	0 (0)	0 (0)	0	<0.001	<0.001	<0.001
Actinobacteria	3.1	2.8	2.7	2.2	0.2	0.41	0.17	0.005
Coriobacteriaceae	3.1	2.8	2.6	2.1	0.2	0.25	0.09	0.002
Proteobacteria	9.1	10.1	12.2	12.2	1.2	0.53	0.06	0.06
Enterobacteriaceae	2.3 (12)	2.5 (11)	3.8 (11)	3.0 (10)	0.4	0.76	0.01	0.24
Comamonadaceae	1.3 (11)	1.2 (12)	1.3 (12)	1.2 (10)	0.2	0.45	0.70	0.50
Oxalobacteraceae	2.0 (12)	2.1 (11)	2.3 (11)	2.3 (10)	0.4	0.87	0.51	0.59
Sphingomonadaceae	1.4 (10)	1.8 (11)	2.0 (10)	2.5 (10)	0.3	0.33	0.17	0.02
Methylobacteriaceae	0.1 (1)	0.1 (1)	0.4 (5)	0.2 (2)	0.1	1	0.04	0.54
Pseudomonas	0.3 (4)	0.3 (3)	0.3 (3)	0.3 (3)	0.1	0.66	0.66	0.76

^bphyla and families within phyla are organized in the order of microbial number; mice with counts are not shown for phyla and families, who have counts for all mice.