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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Mol Nutr Food Res. 2019 Dec 15;64(1):e1900789. doi: 10.1002/mnfr.201900789

Table 5.

Supplementation with 30 mg/kg BW/day XN or its derivatives DXN and TXN alters the fecal bile acid profile

Bile Acid Group CON XN DXN TXN SEM XN vs CON DXN vs CON TXN vs CON
Bile Acid Peak Intensity (LS mean) P-values (Comparisons)
Total 18,866 15,352 29,309 29,618 3,200 0.40 0.02 0.02
Unconjugated Primary 1,555 1,384 997 864 198 0.51 0.04 0.01
CA 450 383 414 257 109 0.64 0.80 0.20
αMCA 107 92 43 35 9 0.24 <0.001 <0.001
βMCA 998 909 539 572 118 0.56 0.004 0.01
Conjugated Primary 13,920 10,660 25,868 26,350 2,828 0.36 0.008 0.01
TCA 1,378 1,069 5,851 6,202 908 0.79 <0.001 <0.001
TCDCA 358 857 399 205 150 0.01 0.83 0.46
TαMCA 748 621 1,009 1,471 154 0.53 0.20 0.001
TβMCA 11,435 8,113 18,608 18,471 1,988 0.20 0.08 0.01
Unconj. Dehydroxylated 1,420 1,289 427 314 147 0.50 <0.001 <0.001
DCA 1,160 1,047 385 282 126 0.49 <0.001 <0.001
UDCA 22 12 4 3 3 0.009 <0.001 <0.001
HDCA 238 229 38 29 23 0.77 <0.001 <0.001
Conjug. Dehydroxylated 1,972 2,019 2,017 2,090 408 0.93 0.93 0.83
TDCA 179 224 264 325 66 0.60 0.33 0.11
TUDCA 939 678 742 507 288 0.49 0.60 0.27
TωMCA 854 1,116 1,011 1,258 228 0.38 0.60 0.20
Ratios
CA/DCA 0.36 0.40 1.78 2.83 0.50 0.95 0.05 0.002
CA/TCA 0.46 0.47 0.12 0.09 0.08 0.87 0.002 0.001
αMCA/TαMCA 0.208 0.180 0.048 0.023 0.036 0.56 0.001 0.0005
βMCA/TβMCA 0.102 0.133 0.032 0.032 0.013 0.07 0.0001 0.0002
Conjugated/Unconj. 5.02 5.06 28.2 48.2 7.1 0.99 0.02 <0.0001