Table 5.
Bile Acid Group | CON | XN | DXN | TXN | SEM | XN vs CON | DXN vs CON | TXN vs CON |
---|---|---|---|---|---|---|---|---|
Bile Acid | Peak Intensity (LS mean) | P-values (Comparisons) | ||||||
Total | 18,866 | 15,352 | 29,309 | 29,618 | 3,200 | 0.40 | 0.02 | 0.02 |
Unconjugated Primary | 1,555 | 1,384 | 997 | 864 | 198 | 0.51 | 0.04 | 0.01 |
CA | 450 | 383 | 414 | 257 | 109 | 0.64 | 0.80 | 0.20 |
αMCA | 107 | 92 | 43 | 35 | 9 | 0.24 | <0.001 | <0.001 |
βMCA | 998 | 909 | 539 | 572 | 118 | 0.56 | 0.004 | 0.01 |
Conjugated Primary | 13,920 | 10,660 | 25,868 | 26,350 | 2,828 | 0.36 | 0.008 | 0.01 |
TCA | 1,378 | 1,069 | 5,851 | 6,202 | 908 | 0.79 | <0.001 | <0.001 |
TCDCA | 358 | 857 | 399 | 205 | 150 | 0.01 | 0.83 | 0.46 |
TαMCA | 748 | 621 | 1,009 | 1,471 | 154 | 0.53 | 0.20 | 0.001 |
TβMCA | 11,435 | 8,113 | 18,608 | 18,471 | 1,988 | 0.20 | 0.08 | 0.01 |
Unconj. Dehydroxylated | 1,420 | 1,289 | 427 | 314 | 147 | 0.50 | <0.001 | <0.001 |
DCA | 1,160 | 1,047 | 385 | 282 | 126 | 0.49 | <0.001 | <0.001 |
UDCA | 22 | 12 | 4 | 3 | 3 | 0.009 | <0.001 | <0.001 |
HDCA | 238 | 229 | 38 | 29 | 23 | 0.77 | <0.001 | <0.001 |
Conjug. Dehydroxylated | 1,972 | 2,019 | 2,017 | 2,090 | 408 | 0.93 | 0.93 | 0.83 |
TDCA | 179 | 224 | 264 | 325 | 66 | 0.60 | 0.33 | 0.11 |
TUDCA | 939 | 678 | 742 | 507 | 288 | 0.49 | 0.60 | 0.27 |
TωMCA | 854 | 1,116 | 1,011 | 1,258 | 228 | 0.38 | 0.60 | 0.20 |
Ratios | ||||||||
CA/DCA | 0.36 | 0.40 | 1.78 | 2.83 | 0.50 | 0.95 | 0.05 | 0.002 |
CA/TCA | 0.46 | 0.47 | 0.12 | 0.09 | 0.08 | 0.87 | 0.002 | 0.001 |
αMCA/TαMCA | 0.208 | 0.180 | 0.048 | 0.023 | 0.036 | 0.56 | 0.001 | 0.0005 |
βMCA/TβMCA | 0.102 | 0.133 | 0.032 | 0.032 | 0.013 | 0.07 | 0.0001 | 0.0002 |
Conjugated/Unconj. | 5.02 | 5.06 | 28.2 | 48.2 | 7.1 | 0.99 | 0.02 | <0.0001 |