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. 2020 Feb 9;26:e922009-1–e922009-12. doi: 10.12659/MSM.922009

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© Med Sci Monit, 2020

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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PCR data confirm that bFGF enhances the expression of the TJ and AJ genes in brain microvascular endothelial cells (BMECs), while FGFR1 and ERK blockers inhibit the protective effect of bFGF. (A–D) Relative expression of genes in BMECs treated with bFGF, PD173074, or PD98059. The expression levels of the ZO-1, occludin, claudin-5, and β-catenin genes were significantly increased in the Combined+bFGF group; however, all the levels were decreased after PD173074 or PD98059 treatment. ** P<0.01 Sham or combined+bFGF group vs. Combined group. ^## P<0.01 vs. Combined+bFGF+PD173074 or Combined+bFGF+PD98059 group vs. Combined+bFGF group. Data are presented as the mean±SD.