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. Author manuscript; available in PMC: 2020 Oct 3.
Published in final edited form as: N Engl J Med. 2019 Oct 3;381(14):1365–1371. doi: 10.1056/NEJMcps1811547

Figure 2. Bone Marrow Specimens.

Figure 2.

In Panel A, the core biopsy specimen shows 50% cellularity, normocellular to mildly hypercellular for the patient’s age. In Panel B, a high number of immature myeloid precursors with mild myeloid predominance and a relative decrease in erythroid maturation are noted. In Panel C, closer examination of the bone marrow core reveals atypical, small hypolobulated megakaryocytes (arrow) with a high nuclear-to-cytoplasmic ratio. In Panels D and E, cytoplasmic vacuoles (arrows) are noted in erythroid and myeloid precursors, respectively.