Table 1. Maternal characteristics of women with intrahepatic cholestasis of pregnancy and the control group.
| Intrahepatic cholestasis of pregnancy (ICP) N = 140 |
Controls N = 560 |
P Values | |
|---|---|---|---|
| Maternal age, years (median (IQR)) | 29 (25–34) | 29 (25–34) | 1 |
| Nulliparous, n (%) | 61 (43.6) | 246 (43.9) | 0.939 |
| White, n (%) | 118 (84.3) | 435 (77.7) | 0.086 |
| BMI, kg/m2 (median (IQR)) | 23.6 (21–27.2) | 22.4 (20–25.1) | 0.216 |
| Personal history of ICP, n (%) | 31 (22.1) | 1 (0.3) | <0.001 |
| Family history of ICP, n (%) | 4 (2.9) | 0 | <0.001 |
| MDR3 gene mutation, n (%) | 6 (4.3) | 0 | <0.001 |
| Preexisting liver disease, n (%) | 6 (4.3) | 13 (2.3) | 0.240 |
| Preexisting coagulopathy, n (%) | 5 (3.6) | 18 (3.2) | 0.957 |
| Gestational diabetes, n (%) | 22 (15.7) | 25 (5.1) | <0.001 |
| Hypertensive disorder, n (%) | 2 (1.4) | 3 (0.5) | 0.574 |