Table 1. Demographic characteristics of prostate cancer patients according to use of androgen deprivation therapy, radiotherapy, and radical prostatectomy.
| Full cohort | Propensity Score–Matched Cohort | |||||||
|---|---|---|---|---|---|---|---|---|
| Variables No. (%) | ADT | RT | RP | P-value | ADT | RT | RP | P-value |
| Total | 8122 | 1797 | 3399 | 1797 | 1797 | 1797 | ||
| Age (mean±SD, years) | 71.28±9.66 | 72.54±7.92 | 67.50±10.63 | <0.001** | 72.63±8.53 | 72.54±7.92 | 72.64±8.26 | 0.923 |
| Age at diagnosis | <0.001** | 0.126 | ||||||
| <50 | 181 (2.23) | 19 (1.06) | 165 (4.85) | 20 (1.11) | 19 (1.06) | 14 (0.78) | ||
| 50–60 | 911 (11.22) | 109 (6.07) | 682 (20.06) | 124 (6.90) | 109 (6.07) | 112 (6.23) | ||
| 60–70 | 2266 (27.90) | 483 (26.88) | 1147 (33.76) | 489 (27.21) | 483 (26.88) | 508 (28.27) | ||
| 70–80 | 3251 (40.02) | 893 (49.69) | 961 (28.27) | 817 (45.47) | 893 (49.69) | 822 (45.74) | ||
| >80 | 1513 (18.63) | 293 (16.30) | 444 (13.06) | 347 (19.31) | 293 (16.30) | 341 (18.98) | ||
|
Follow-up period (mean±SD, years) |
6.01 (4.34) | 5.16 (3.70) | 5.31 (3.93) | <0.001** | 5.89 (4.29) | 5.16 (3.70) | 5.05 (3.83) | <0.001** |
| Comorbidity | ||||||||
| Alcohol abuse | 16 (0.20) | 4 (0.22) | 4 (0.12) | 0.592 | 10 (0.56) | 4 (0.22) | 2 (0.11) | 0.038* |
| Tobacco use disorder | 1108 (13.64) | 266 (14.80) | 362 (10.65) | <0.001** | 228 (12.69) | 266 (14.80) | 240 (13.36) | 0.167 |
| Obesity | 15 (0.18) | 7 (0.39) | 7 (0.21) | 0.238 | 6 (0.33) | 7 (0.39) | 4 (0.22) | 0.661 |
| Diabetes mellitus | 1586 (19.53) | 333 (18.53) | 617 (18.15) | 0.193 | 319 (17.75) | 333 (18.53) | 317 (17.64) | 0.750 |
| Hypertension | 3964 (48.81) | 938 (52.20) | 1449 (42.63) | <0.001** | 936 (52.09) | 938 (52.20) | 928 (51.64) | 0.939 |
| Hyperlipidemia | 1518 (18.69) | 367 (20.42) | 707 (20.80) | 0.018* | 336 (18.70) | 367 (20.42) | 325 (18.09) | 0.180 |
| Coronary heart disease | 1706 (21.00) | 412 (22.93) | 553 (16.27) | <0.001** | 363 (20.20) | 412 (22.93) | 363 (20.20) | 0.068 |
| Chronic kidney disease | 390 (4.80) | 101 (5.62) | 165 (4.85) | 0.340 | 72 (4.01) | 101 (5.62) | 103 (5.73) | 0.031* |
| Chronic liver disease | 891 (10.97) | 188 (10.46) | 344 (10.12) | 0.382 | 158 (8.79) | 188 (10.46) | 173 (9.63) | 0.237 |
| Cerebral vascular accident | 1086 (13.37) | 217 (12.08) | 3553(10.39) | <0.001** | 199 (11.07) | 217 (12.08) | 228 (12.69) | 0.321 |
| Crohn’s disease | 65 (0.80) | 16 (0.89) | 25 (0.74) | 0.834 | 17 (0.95) | 16 (0.89) | 9 (0.50) | 0.254 |
| Ulcerative colitis | 5 (0.06) | 0 (0.00) | 1 (0.03) | 0.475 | 2 (0.11) | 0 (0.00) | 0 (0.00) | 0.135 |
| Rheumatoid arthritis | 98 (1.21) | 23 (1.28) | 21 (0.62) | 0.012* | 26 (1.45) | 23 (1.28) | 15 (0.83) | 0.215 |
| GI bleeding | 359 (4.42) | 92 (5.12) | 122 (3.59) | 0.024* | 72 (4.01) | 92 (5.12) | 68 (3.78) | 0.107 |
| Medication use | ||||||||
| Antiplatelet | 5550(68.33) | 1161(64.61) | 1607(47.28) | <0.001** | 1247(69.39) | 1161(64.61) | 980(54.54) | <0.001** |
| Anticoagulation | 539 (6.64) | 126 (7.01) | 137 (4.03) | <0.001** | 108 (6.01) | 126 (7.01) | 92 (5.12) | 0.058 |
| NSAID | 4136(50.92) | 740(41.18) | 183 (5.38) | <0.001** | 887(49.36) | 740(41.18) | 100 (5.56) | <0.001** |
Abbreviations: ADT, androgen deprivation therapy; RT, radiotherapy; RP, radical prostatectomy; GI, gastrointestinal; SD, standard deviation.
*P <0.05
**P<0.001