Table 4. Associations of changes in monocytes subsets, ILC2s, and β2AR expression within Mo subsets with anthropometric and metabolic features after dietary restriction.

Dependent variable	Regressors	β±S.E.	T	p-level
ΔNon-Classical monocytes (NCM; CD14-CD16++). Adjusted R2 = 0.94
	Intercept		-4.07	<0.00013
	ΔLeptin levels	-0.27±0.12	-2.22	<0.03
	ΔHDL-C	-0.24±0.12	-1.96	<0.046
ΔIntermediate monocytes (IM; CD14+CD16+) Adjusted R2 = 0.134
	Intercept		2.25	<0.04
	ΔLeptin levels	-0.34±0.12	-2.91	<0.01
	ΔHDL-C	-0,24±0.12	-2.02	<0.047
ΔClassical monocytes (CM; CD14+CD16-) Adjusted R2 = 0.157
	Intercept		3.79	<0.0001
	ΔHDL-cholesterol	0.37±0.11	3.20	<0.002
ΔCD16+/CD16- ratio Adjusted R2 = 0.316
	Intercept		-4.49	<0.00003
	ΔHDL-Cholesterol	-0.34±0.10	-3.29	<0.0017
	ΔLeptin	-0.31±0.11	-2.82	<0.0065
	ΔBMI	-0.32±0.11	-2.82	<0.0065
	ΔREE	0.23±0.11	2.08	<0.04
ΔGroup 2 innate lymphoid cells (ILC2s) Adjusted R2 = 0.143
	Intercept		7.37	<0.0000001
	ΔHOMA-IR	-0.40±0.12	-3.42	<0.0011
Δβ2AR expression on NCM Adjusted R2 = 0.401
	Intercept		-5.04	<0.000005
	ΔBMI	-0.53±0.10	-5.12	<0.000003
	ΔLeptin	0.49±0.11	4.66	<0.000018
	ΔHDL-C	0.25±0.10	2.63	<0.011
	ΔHOMA-IR	-0.24±0.10	-2.37	<0.021
Δβ2AR expression on IM Adjusted R2 = 0.058
	Intercept		-3.09	<0.0030
	ΔBMI	-0.27±0.12	-2.22	<0.029
Δβ2AR expression on CM Adjusted R2 = 0.258
	Intercept		-4.54	<0.000026
	ΔBMI	-0.53±0.11	-4.65	<0.000018
	ΔLeptin	0.25±0.11	2.19	<0.032

The associations were evaluate by multiple regression (n = 52). p<0.05 was considered statistically significant.

Δ, delta; BMI, body mass index; REE, energy expenditure; β2AR, beta-2 adrenergic receptor; NCM, non-classical monocytes (CD14^-CD16⁺⁺); IM, intermediate monocytes (CD14⁺CD16⁺); CM, classical monocytes (CD14⁺CD16⁺).