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. 2020 Jan 15;7(1):191139. doi: 10.1098/rsos.191139

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© 2020 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 5. — TEM characterization of human osteosarcoma MG-63 cell incubation with 200 µg ml⁻¹ Zn_0.5Fe_2.5O₄/SiO₂ NPs for 0.5 h (a,b), 2 h (c, d), 24 h (e,f). The NPs just attached to the cytomembrane did not internalize into the cytoplasm at 0.5 h incubation. However, the NPs internalized into human osteosarcoma MG-63 cells and were located in the lysosomes after 2 h incubation. With the extension of the incubation time, the amount of NPs in lysosomes gradually increased.