Table 1. Patient characteristics of each study.
| First Author | Treatment | Number(n) | Age* (year) | Gender (M/F,n) | HBV/HCV/Alcohol /others (n) | ECOG (0/1/2/3,n) | Child-Pugh (A/B/C,n) | BCLC stage (A/B/C/D,n) | Treatment sessions* (n) | Biggest Tumor size* (cm) | Lesion location (Unilobar/ Bilobar,n) | Liver involvement (≤50%/>50%,n) | PVTT (yes/no,n) | Total Bilirubin (mg/dl,n) |
ALT (U/L,n) | AFP(ng/ml) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pitton 2015[39] | DEB-TACE | 12 | 70.5±9.0 | 10/2 | 1/4/5/3 | NA | 9/3/0 | 1/11/0/0 | 3.8±2.6 | 6.1±3.76 | 5/7 | 12/0 | NA | 164±529 | NA | 164±529 |
| TARE | 12 | 71.8±7.2 | 8/4 | 0/5/5/2 | NA | 10/2/0 | 0/12/0/0 | 1.5±0.5 | 6.1±3.64 | 4/8 | 12/0 | NA | 3308±10204 | NA | 3308±10204 | |
| McDevitt 2017 | DEB-TACE | 26 | 64 (51–85)# | 22/4 | 1/5/4/16 | 8/10/7/1 | 18/8/0 | 0/6/20/0 | 1.5±1.1 | 8.9 | -/19 | 23/3 | 6/20 | > 400/≤400 13/13 | NA | > 400/≤400 13/13 |
| [21] | TARE | 24 | 61 (53–86)# | 21/3 | 0/9/3/12 | 7/10/6/1 | 15/9/0 | 0/5/19/0 | 1.6±0.5 | 9.0 | -/17 | 22/2 | 5/14 | > 400/≤400 7/17 | NA | > 400/≤400 7/17 |
| Akinwande 2016[19] | DEB-TACE | 48 | 61.5 (19–81)# | 40/8 | 4/9/4/0 | <1/≥1 36/12 | 17/26/5 | NA | 2 | NA | NA | 47/1 | 14/20 | 43.70 (2–37424) | >250/≤250 0/48 | 43.70 (2–37424)# |
| TARE | 48 | 66.5 (27–82)# | 33/8 | 0/11/15/0 | <1/≥1 3/45 | 16/28/4 | NA | 1.67 | NA | NA | 45/3 | 16/16 | 26.5 (2–61378) | >250/≤250 0/48 | 26.5 (2–61378)# | |
| Lance 2011[20] | DEB-TACE | 35 | 61 (51–84)# | 28/7 | 0/11/3/14 | 6/18/10/2 | 24/11/0 | NA | 1.5±0.13 | 6.0 | -/26 | 35/0 | NA | ≥400/<400 16/19 | NA | ≥400/<400 16/19 |
| TARE | 38 | 63 (44–85)# | 33/5 | 0/13/8/14 | 6/24/7/1 | 31/7/0 | NA | 1.37±0.1 | 6.1 | -/22 | 38/0 | NA | ≥400/<400 14/24 | NA | ≥400/<400 14/24 | |
| Carr 2010[29] | TARE | 99 | NA | 70/29 | 9/30/37/- | NA | NA | NA | NA | NA | -/43 | NA | 28/71 | 3–1.5/<1.5 13/86 | NA | ≥25/<25 58/41 |
| cTACE | 691 | NA | 518/173 | 97/132/217/- | NA | NA | NA | NA | NA | -/354 | NA | 295/396 | 3–1.5/<1.5 173 /518 | NA | ≥25/<25 465/226 | |
| Kooby 2010[14] | TARE | 27 | 58.7±10.8 | 23/4 | -/10/-/- | NA | 13/14/0 | NA | 1.2±1.1 | 7.4±3.2 | NA | NA | 14/13 | NA | NA | 801±1037 |
| cTACE | 44 | 61.0±9.9 | 36/8 | -/25/-/- | NA | 22/22/0 | NA | 1.3±1.2 | 7.4±5.1 | NA | NA | 13/31 | NA | NA | 690±976 | |
| Lewandowski 2009[17] | TARE | 43 | 68 | 38/5 | 2/14/9/15 | NA | 24/19/0 | 0/34/9/0 | 1.8(1–6) | 5.6 | NA | NA | 0/43 | >2/≤2 6/37 | NA | NA |
| cTACE | 43 | 65 | 36/7 | 6/16/10/7 | NA | 23/18/2 | 0/37/4/2 | 2.0 (1–5) | 5.7 | NA | NA | 0/43 | >2/≤2 10/33 | NA | NA | |
| Moreno 2013[34] | TARE | 61 | 64 | 49/12 | 0/8/12/41 | 51/7/3/0 | 53/8/0 | 12/34/14/0 | NA | 5.0 | NA | NA | NA | 0.80 (0.63–1.48) | 51 (19–249) | 22.1 (1.9–397000) |
| cTACE | 55 | 66 | 43/12 | 0/7/13/35 | 40/15/0/0 | 44/11/0 | 23/13/19/0 | NA | 5.0 | NA | NA | NA | 1.1 (0.80, 1.60) | 54 (23–890) | 52 (0.6–264300) | |
| Salem 2016[41] | TARE | 24 | 62 (58–65) | 17/7 | 3/12/4/3 | NA | 12/12/0 | 18/6/0/0 | 1.3±0.5 | 3.0 | 17/7 | NA | 0/24 | 1.3 (1.2–1.7) | NA | <200/≥200 21/3 |
| cTACE | 21 | 64 (62–70) | 16/5 | 1/10/1/5 | NA | 15/6/0 | 17/4/0/0 | 1.7±1.1 | 2.6 | 14/7 | NA | 0/21 | 0.9 (0.8–1.5) | NA | <200/≥200 19/2 | |
| El 2015[37] | TARE | 44 | 66.1±8.9 | 36/8 | 6/8/10/9 | 44/0/0/0 | 37/7/0 | 0/44/0/0 | 1.4±0.6 | 6.4 (2.2–21) | 24/20 | 44/0 | NA | >2/≤2 5/39 | NA | 11 299±46452 |
| cTACE | 42 | 58.3±6.7 | 38/4 | 1/36/0/0 | 42/0/0/0 | 33/9/0 | 0/42/0/0 | 2.2±1.4 | 5.7 (2.5–15) | 40/2 | 42/0 | NA | >2/≤2 3/39 | NA | 697.6±2834 | |
| Kolligs 2015[18] | TARE | 13 | 65.8±6.73 | 11/2 | NA | 10/3/0/0 | 12/1/0 | 5/5/3/0 | 1±0.0 | NA | 6/7 | NA | NA | Median 1.00 | NA | 636.0±2171.8 |
| cTACE | 15 | 66.7±9.04 | 13/2 | NA | 12/3/0/0 | 13/2/0 | 4/8/3/0 | 3.4±2.90 | NA | 11/4 | NA | NA | Median 1.08 | NA | 2624.7±9525.3 | |
| Soydal 2016[16] | TARE | 40 | 62.28±9.73 | 33/7 | NA | NA | 0/28/12 | NA | 1±0 | 6.55±4.60 | NA | 38/2 | NA | 0.94±0.48 | 52.71±39.04 | NA |
| cTACE | 40 | 66.15±7.81 | 34/6 | NA | NA | 0/34/6 | NA | 2.8±1.1 | 7.12±3.85 | NA | 35/5 | NA | 1.04±0.90 | 47.79±28.18 | NA | |
| Arabi 2014[28] | DEB-TACE | 35 | 67.1±9.6 | 24/11 | 10/19/-/- | NA | 24/11/0 | NA | 1.45 | 6 (1.3–16.3) | NA | NA | NA | median 5.5 | median 74 | NA |
| cTACE | 19 | 66.7±9.6 | 15/4 | 7/8/-/- | NA | 17/2/0 | NA | 1.31 | 7(3–12.3) | NA | NA | NA | median 3 | median 7 | NA | |
| Dhanasekaran 2010[30] | DEB-TACE | 45 | 59.96±11.45 | 35/10 | 5/20/7/13 | NA | 22/11/12 | NA | 1.27±0.6 | 5.49±4.29 | NA | NA | 11/34 | NA | NA | NA |
| cTACE | 26 | 58.96±13.3 | 19/7 | 3/11/3/9 | NA | 11/11/4 | NA | 1.46±0.8 | 7.40±4.91 | NA | NA | 2/24 | NA | NA | NA | |
| Kloeckner 2015[31] | DEB-TACE | 76 | NA | 68/8 | 10/20/30/10 | 53/20/2/1 | 51/22/3 | 8/34/30/4 | 2.96±1.79 | NA | NA | NA | 11/65 | ≥2/<2 12/64 | NA | NA |
| cTACE | 174 | NA | 140/30 | 14/47/86/15 | 110/61/2/1 | 103/64/7 | 30/59/77/8 | 4.00±3.09 | NA | NA | NA | 36/138 | ≥2/<2 28/136 | NA | NA | |
| Kucukay 2015[8] | DEB-TACE | 53 | 63.8±10.9 | 57/13 | NA | NA | NA | 29/19/5/0 | NA | NA | NA | NA | NA | 1.1±0.3 | NA | NA |
| cTACE | 73 | 64.8±9.0 | 62/11 | NA | NA | NA | 29/40/4/0 | NA | NA | NA | NA | NA | 1.0±0.2 | NA | NA | |
| Lammer 2010 [38] | DEB-TACE | 93 | 67.3±9.1 | 79/14 | 16/22/43/21 | 74/19/0/0 | 77/16/0 | 24/69/0/0 | NA | 8.89±5.21 | -/41 | NA | 0/93 | >3/≤3 0/93 | >250/≤250 0/93 | NA |
| cTACE | 108 | 67.4±8.8 | 95/13 | 18/18/57/25 | 80/28/0/0 | 89/19/0 | 29/79/0/0 | NA | 8.92±5.93 | -/45 | NA | 0/108 | >3/≤3 0/108 | >250/≤250 0/108 | NA | |
| Lee 2017[32] | DEB-TACE | 106 | 64 (38–90) | 80/26 | 80/11/-/15 | NA | 85/21/0 | 20/77/9/0 | NA | 3.4 (1.3–12.1) | 75/31 | NA | 4/102 | 0.7 (0.3–2.8) | 31 (8–101) | 21 (1–22 392) |
| cTACE | 144 | 61 (30–89) | 124/20 | 119/14/-/11 | NA | 95/49/0 | 49/73/22/0 | NA | 2.5 (1.0–14.0) | 86/58 | NA | 8/136 | 0.7 (0.1–2.3) | 31 (11–407) | 24 (1–83 000) | |
| Megias 2015[33] | DEB-TACE | 30 | 64.8±9.56 | 24/6 | 4/19/10/4 | NA | 14/16/0 | NA | 1.4 (1–5) | NA | -/5 | NA | 1/29 | NA | NA | NA |
| cTACE | 30 | 61.9±10.59 | 21/9 | 5/20/10/2 | NA | 19/11/0 | NA | 1.23 (1–4) | NA | -/10 | NA | 4/26 | NA | NA | NA | |
| Rahman 2016[9] | DEB-TACE | 45 | 63±13 | 36/9 | 14/5/-/14 | -/-/-/0 | 19/26/0 | 9/36/0/0 | 2.13±1.01 | 7.38±4.81 | 45/- | 45/0 | NA | NA | NA | NA |
| cTACE | 34 | 61±10 | 26/8 | 13/4/-/4 | -/-/-/0 | 11/13/0 | 11/23/0/0 | 1.44±0.82 | 8.95±5.87 | 34/- | 34/0 | NA | NA | NA | NA | |
| Recchia 2012[10] | DEB-TACE | 35 | 72 (53–80) | 25/10 | NA | NA | NA | NA | NA | 4.12(1–9) | NA | 35/0 | NA | ≥3/<3 0/35 | ≥270/<270 0/35 | NA |
| cTACE | 70 | 70 (47–80) | 50/20 | NA | NA | NA | NA | NA | 53(2–9) | NA | 70/0 | NA | ≥3/<3 0/70 | ≥270/<270 0/70 | NA | |
| Song 2012[7] | DEB-TACE | 60 | 61.7±9.8 | 42/18 | 44/8/4/4 | NA | 56/4/0 | 27/33/0/0 | NA | 4.2±2.8 | NA | NA | NA | NA | NA | <200/≥200 48/12 |
| cTACE | 69 | 59.4±11.2 | 48/21 | 46/8/12/3 | NA | 62/6/0 | 28/41/0/0 | NA | 5.0±3.1 | NA | NA | NA | NA | NA | 48/21 | |
| Hannah 2011[42] | DEB-TACE | 16 | 67.3±9.8 | 14/2 | 4/4/-/8 | 9/7/0/0 | 14/2/0 | 2/9/5/0 | NA | NA | NA | NA | NA | 1.17±0.58 | 59.9±29.6 | 1803.4±5409.2 |
| cTACE | 14 | 56.6±13.4 | 11/3 | 4/0/-/10 | 10/2/2/0 | 14/0/0 | 1/10/3/0 | NA | NA | NA | NA | NA | 1.13±0.58 | 52.7±29.2 | 8069.2±23342.3 | |
| Philipp 2011[36] | DEB-TACE | 22 | 70.32±7.06 | 18/4 | -/-/2/14 | NA | 22/0/0 | 1/17/3/0 | 2.09±1.15 | 7.44±3.37 | NA | NA | NA | NA | NA | NA |
| cTACE | 22 | 67.72±9.02 | 19/3 | -/-/7/12 | NA | 22/0/0 | 4/15/2/0 | 1.95±1.62 | 6.98±3.81 | NA | NA | NA | NA | NA | NA | |
| Golfieri 2014[11] | DEB-TACE | 89 | 68.9±8.0 | 66/23 | -/-/16/0 | 64/25/0/0 | 75/14/0 | 41/26/22/0 | 2 (1–5)# | 3.1±1.6 | -/17 | NA | NA | NA | NA | NA |
| cTACE | 88 | 68.3±8.0 | 69/19 | -/-/20/0 | 67/21/0/0 | 77/11/0 | 41/23/24/0 | 2 (1–4)# | 3.4±1.9 | -/20 | NA | NA | NA | NA | NA | |
| Sacco 2011[40] | DEB-TACE | 33 | 71.3±7.2 | 23/10 | 4/22/-/7 | NA | 29/4/0 | 22/11/0/0 | 1.1 | 44.7±26.8 | 25/- | NA | NA | NA | 74.1±62.2 | 662±1679 |
| cTACE | 34 | 68.7±8.1 | 22/12 | 4/25/-/5 | NA | 25/9/0 | 22/12/0/0 | 1.4 | 38.5±18.9 | 28/- | NA | NA | 1.25±1 | 54.0±38.8 | 67.5±202 | |
| Thomas 2010[44] | DEB-TACE | 102 | 67.0±9.2 | 88/14 | 14/20/41/27 | 74/19/0/0 | 77/16/0 | 26/76/0/0 | NA | NA | 52/41 | NA | NA | NA | NA | 25.62±890.28 |
| cTACE | 110 | 67.3±8.8 | 97/13 | 13/12/52/33 | 80/28/0/0 | 89/19/0 | 29/81/0/0 | NA | NA | 63/45 | NA | NA | NA | NA | 27.54±2400.19 | |
| Nicolini 2013[35] | DEB-TACE | 22 | 57.2±6.5 | 19/3 | 8/10/-/4 | NA | NA | 14/8/0/0 | NA | 1.8 (0.7–4.5) | NA | NA | NA | NA | NA | >70/≤70 3/19 |
| cTACE | 16 | 55.6±6.5 | 15/1 | 3/12/-/1 | NA | NA | 7/9/0/0 | NA | 2.2 (1–10) | NA | NA | NA | NA | NA | >70/≤70 5/11 |
* Mean±SD, # Median(range), NA Not Available, cTACE Conventional transarterial chemoembolization, DEB-TACE Drug-eluting beads, TARE Transarterial radioembolization, PVTT Portal vein tumor thrombus