Table 3:

Health outcomes in children at 3 years of age per interquartile range increase in the Frequency of Use Score for household use of cleaning products^*†

Outcome phenotype	OR (95% CI)						Sex‡ FUS p value		Trend¶ p value
	Overall sample population (IQRI = 13 points) n = 2022		Boys (IQRI = 14 points) n = 1047		Girls (IQRI = 13 points) n = 975
	Unadj.	Adj.	Unadj.	Adj.	Unadj.	Adj.	Unadj.	Adj.
Recurrent wheeze	1.45 (1.20–1.75)	1.35 (1.11–1.64)	1.27 (0.97–1.66)	1.17 (0.89–1.55)	1.78 (1.33–2.38)	1.66 (1.22–2.25)	0.07	0.09	0.0001
Recurrent wheeze and atopy	1.65 (1.15–2.35)	1.49 (1.02–2.16)	1.37 (0.81–2.29)	1.19 (0.98–1.05)	2.18 (1.26–3.66)	2.14 (1.17–3.86)	0.18	0.18	0.003
Asthma diagnosis	1.44 (1.16–1.78)	1.37 (1.09–1.70)	1.36 (1.00–1.85)	1.32 (0.96–1.81)	1.60 (1.14–2.23)	1.48 (1.03–2.09)	0.40	0.52	0.0004
Atopy	1.10 (0.94–1.29)	1.14 (0.96–1.35)	1.03 (0.81–1.29)	1.11 (0.87–1.41)	1.20 (0.94–1.51)	1.17 (0.90–1.50)	0.34	0.29	0.12

Note: Adj. = adjusted, CI = confidence interval, FUS = Frequecy of Use Score, IQRI = interquartile range increase, OR = odds ratio, Unadj. = unadjusted.

^*We derived all values using multivariable logistic regression models.

^†Models were adjusted for prenatal or early-life exposure to tobacco smoke, sex, child’s ethnicity, parental asthma history, household income, city/location, visible mould in the home and pet ownership.

^‡For the sex-stratified analysis, we adjusted for all covariates except sex. The p value of the interaction term when included in the regression model for the overall sample is reported.

^¶We used a 1-sided Cochran–Armitage test (unadjusted) to evaluate increasing trend, by continuous FUS score for each health outcome.