Figure 6. Salt bridge network around the F198 side chain. (A, B and C) Structures at specific time points of the WT simulation 2, Y218N simulation 1, and E196K simulation 2, respectively. Secondary structure color schemes are cyan for HA, blue for HB and HC, where the transparent helix is HC. Residues E/K196, F198, T199, D202, and R156 are shown in sticks and hydrogen bonds are indicated with dotted blue lines. (far right) Relevant contacts are plotted over time.