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. 2020 Feb 19;6(8):eaaz0374. doi: 10.1126/sciadv.aaz0374

Fig. 6. Restoration of the antibacterial function of MAIT cells in HIV-1 infection.

Fig. 6

(A) PBMCs with or without pDC enrichment were stimulated with HIVNL4-3 for 24 hours before the detection of IFN-α in the supernatant by ELISA. (B) Levels of IP-10 and IL-10 in the supernatant of PBMCs stimulated with HIVNL4-3 in the presence of an anti-IFNAR2 (αIFNAR; 5 μg/ml) or isotype control antibody for 24 hours. (C) Responses of MAIT cells in PBMCs stimulated with HIVNL4-3 in the presence of an anti-IFNAR2 or anti–IL-10R antibody for 3 days before stimulation with E. coli. (D) Responses of MAIT cells from ART-treated (ART; n = 8) or untreated (VIR; n = 6) HIV-1–infected patients upon E. coli stimulation in the presence of IL-12 or the anti–IL-10R antibody. (E) Responses of MAIT cells in PBMCs from HC, VIR, or ART subjects (n = 9 in each group) to the H37Ra strain of Mtb. (F) Responses of MAIT cells from VIR or ART subjects (n = 10 in each group) upon H37Ra stimulation in the presence of an anti–IL-10R or isotype control antibody.