Table 4.
Chronic GVHD symptoms by self-reported and NIH calculated chronic GVHD severity at enrollment
| Self-reported cGVHD severity | |||
| Symptoms | None1/Mild, Mean (SD) (n=36) | Moderate/Severe,2Mean (SD) (n=31) | p-value3 |
| Energy | 19.0 (13.1) | 38.1 (22.0) | <.001 |
| Skin | 9.2 (11.9) | 21.6 (19.5) | 0.003 |
| Nutrition | 3.2 (8.0) | 7.0 (8.6) | 0.070 |
| Nutrition - modified3 | 4.1 (10.1) | 8.7 (10.8) | 0.069 |
| Lung | 2.6 (4.4) | 4.2 (7.7) | 0.315 |
| Lung - modified4 | 3.0 (5.1) | 4.9 (9.4) | 0.304 |
| Psychological | 12.3 (13.7) | 21.4 (13.4) | 0.023 |
| Eye | 32.9 (26.3) | 57.0 (25.8) | <.001 |
| Mouth | 14.6 (17.0) | 25.8 (30.9) | 0.076 |
| Summary | 13.4 (7.9) | 25.0 (9.6) | <.001 |
| Summary - modified3 | 13.6 (8.0) | 25.3 (9.9) | <.001 |
| cGVHD severity per NIH criteria | |||
| Mild, Mean (SD) (n=10) | Moderate/Severe, Mean (SD) (n=58) | p-value3 | |
| Energy | 11.1 (10.8) | 30.9 (20.0) | 0.003 |
| Skin | 3.0 (3.5) | 17.1 (17.5) | <.001 |
| Nutrition | 1.5 (3.4) | 5.6 (8.9) | 0.014 |
| Nutrition - modified4 | 1.9 (4.2) | 7.0 (11.2) | 0.014 |
| Lung | 0.0 (0.0) | 4.0 (6.6) | <.001 |
| Lung - modified4 | 0.0 (0.0) | 4.5 (7.8) | <.001 |
| Psychological | 10.0 (10.2) | 17.7 (17.3) | 0.180 |
| Eye | 20.0 (16.8) | 48.4 (28.2) | 0.003 |
| Mouth | 8.8 (13.2) | 21.8 (26.1) | 0.024 |
| Summary | 7.8 (6.0) | 20.8 (9.9) | <.001 |
| Summary - modified4 | 7.8 (6.1) | 21.0 (10.1) | <.001 |
1
5 patients indicated they had “none” and “0” or “1” severity on a 0–10 scale. They are included in the study because they had mild, moderate or severe cGVHD per NIH criteria.
2
1 patient did not report chronic GVHD severity but was NIH severe so was grouped with the self-reported moderate/severe group
3
Based on T-test
4
Modified from the original by deletion of two items, see text