Extended Data Fig. 2:

Assessment of BCL11A and other mRNAs expressed in newborn and adult erythroid cells using RNA sequencing

a, Scatter plots of gene expression, determined from RNA-sequencing reads, expressed as log₂ TPM (transcripts per million reads) in adult and newborn primary erythroid cells. ‘r’ represents the Pearson correlation coefficient. b, Expression of BCL11A, represented as log₂ TPM, between newborn (n = 2) and adult (n = 2) erythroid cells. Error bars show s.d. c, BCL11A mRNA structure and splicing is comparable between developmental stages. Sashimi plots depicting exon-exon spanning reads are shown for annotated isoforms of BCL11A. d, Representation of known BCL11A isoforms. e, Relative abundances of BCL11A isoforms in newborn (n = 2) and adult (n = 2). Error bars show s.d. No transcript was differentially expressed at P < 0.01 between the newborn and adult cells.