Table 1.
Changes of sex steroid profiles in peripheral blood during the perioperative period
| Before Surgery | After Surgery | |||||
|---|---|---|---|---|---|---|
| Reference Intervala | Baseline | 60 min After ACTH | DST1 | POD 7 | POD 44 | |
| LH, mIU/mL | 0.8-5.7 | < 0.07 | N/A | N/A | 3.55 | 20.65 |
| FSH, mIU/mL | 2.0-8.3 | < 0.30 | N/A | N/A | 6.59 | 20.27 |
| Estrone, pmol/L | 68-2135 | 2757 | 2927 | 2993 | 56 | 100 |
| Estradiol, pmol/L | 46-1605 | 378 | 451 | 448 | 11 | 55 |
| DHEA, nmol/L | 2.5-46.76 | 11 | 15 | 9.3 | 5.0 | 4.7 |
| Androstenedione, nmol/L | 1.5-8.36 | 23 | 24 | 23 | 1.6 | 1.3 |
| Δ5A-diol, nmol/L | N/A | 1.6 | 1.8 | 1.3 | 1.1 | 1.1 |
| Testosterone, nmol/L | 9.2-29.15 | 4.6 | 5.0 | 5.4 | 2.2 | 8.4 |
| DHT, pmol/L | 568-23395 | 757 | 826 | 826 | 172 | 585 |
| 11-OHAD, nmol/L | N/A | 6.0 | 8.4 | 0.9 | 5.5 | 6.3 |
| 11-ketoAD, nmol/L | N/A | 1.3 | 1.3 | 0.4 | 1.1 | 1.3 |
| 11-OHT, pmol/L | N/A | 296 | 558 | 99 | 526 | 788 |
| 11-ketoT, pmol/L | N/A | 1058 | 728 | 132 | 926 | 1488 |
| SHBG, nmol/L | 10-57 | 59 | N/A | N/A | N/A | 40 |
| Aldosterone, ng/dL | 3-15 | 18.6 | 21.9 | 11.1 | 15.5 | 8.1 |
| Renin activity, ng/mL/h | 1.0-3.9 | 0.3 | 0.3 | 0.6 | 0.2 | 0.2 |
| Serum potassium, mmol/L | 3.5-5.0 | 4.3 | N/A | N/A | 5.4 | 4.1 |
| Potassium replacement, mmol/day | N/A | 98 | N/A | N/A | 48 | 24 |
Steroid profiles in peripheral blood before and after surgery are shown. Preoperative evaluation suggested adrenocorticotropin-independent production of estrogens and androgens except for DHEA and 11-oxygenated androgens. After surgery, estrogen levels immediately normalized, and gonadotropins gradually increased, whereas adrenal androgens, other than 11-oxygenated androgens, decreased. SHBG was slightly elevated at baseline, and normalized after the surgery. Reference intervals were taken from previous studies [5, 6].
Abbreviations: Δ5A-diol, 5-androstene-3β,17β-diol; 11-ketoAD, 11-ketoandrostenedione; 11-ketoT, 11-ketotestosterone; 11-OHAD, 11-β-hydroxy-androstenedione; 11-OHT, 11-hydroxytestosterone; DHEA, dehydroepiandrosterone; DHT, dihydrotestosterone; DST1, 1 mg dexamethasone suppression test; FSH, follicle-stimulating hormone; LH, luteinizing hormone; N/A, not available; POD, postoperative day; SHBG, sex hormone binding globulin.