Table 2.
More Details of Chemotherapy in All 75 Patients with KRAS Mutations
| Case | KRAS mutation | KRAS comutation | 1st-line chemotherapy | 2nd-line chemotherapy |
|---|---|---|---|---|
| 1 | Q61H | EGFR-KRAS | Pemetrexed + carboplatin | Nab-paclitaxel + cisplatin |
| 2 | G12C | TP53-KRAS | Pemetrexed | No |
| 3 | G13D | EGFR-KRAS | Pemetrexed + carboplatin + bevacizumab | No |
| 4 | Q61L | TP53-KRAS | Pemetrexed + cisplatin + bevacizumab | Nab-paclitaxel + bevacizumab |
| 5 | G12C | Others | Pemetrexed + cisplatin + bevacizumab | Pemetrexed + cisplatin + bevacizumab |
| 6 | G12C | TP53-KRAS | Pemetrexed | No |
| 7 | G12D | STK11-KRAS | Pemetrexed + bevacizumab | No |
| 8 | G12S | TP53-KRAS | Pemetrexed + lobaplatin | No |
| 9 | G12V | Others | Pemetrexed + carboplatin | No |
| 10 | G12V | Others | Pemetrexed + cisplatin | Pemetrexed + bevacizumab |
| 11 | G12V | Others | Pemetrexed + carboplatin | Liposome paclitaxel |
| 12 | G12C | TP53-KRAS | Paclitaxel + carboplatin + bevacizumab | Bevacizumab |
| 13 | G12S | TP53-KRAS | Pemetrexed + carboplatin | Bevacizumab |
| 14 | Unknown | EGFR-KRAS | No | No |
| 15 | G12V | Others | Pemetrexed + cisplatin + bevacizumab | Docetaxel + lopaplatin |
| 16 | G12C | Others | Pemetrexed + carboplatin + bevacizumab | Docetaxel |
| 17 | G12C | Others | Pemetrexed + carboplatin + bevacizumab | No |
| 18 | G12C | TP53-KRAS | No | No |
| 19 | G12C | TP53-KRAS | Pemetrexed + carboplatin + bevacizumab | No |
| 20 | G12V | others | Pemetrexed + cisplatin | Pemetrexed + bevacizumab |
| 21 | G12C | others | Pemetrexed + carboplatin + bevacizumab | No |
| 22 | G12C | others | Pemetrexed + nedaplatin | No |
| 23 | G12A | TP53-KRAS | Pemetrexed + cisplatin | Pemetrexed + carboplatin + bevacizumab |
| 24 | G12C | TP53-KRAS | Gemcitabine + cisplatin | Docetaxel |
| 25 | G12V | TP53-KRAS | Pemetrexed | No |
| 26 | G12C | others | Pemetrexed + cisplatin + bevacizumab | No |
| 27 | Q61H | others | Pemetrexed + cisplatin + bevacizumab | No |
| 28 | G13D | others | Pemetrexed + cisplatin | Docetaxel + bevacizumab |
| 29 | G12D | STK11-KRAS | Pemetrexed + nedaplatin | No |
| 30 | G12V | others | Pemetrexed + carboplatin | No |
| 31 | G12A | others | Pemetrexed + cisplatin | Paclitaxel + nedaplatin |
| 32 | G12A | others | Pemetrexed + cisplatin | Paclitaxel + nedaplatin |
| 33 | unknown | others | Cisplatin/carboplatin | Other |
| 34 | G12C | TP53-KRAS | Pemetrexed + carboplatin | No |
| 35 | G12D | others | Pemetrexed + cisplatin + bevacizumab | Pemetrexed + cisplatin + bevacizumab |
| 36 | G12C | TP53-KRAS | Nab-paclitaxel | No |
| 37 | G12C | EGFR-KRAS | Pemetrexed + nedaplatin | No |
| 38 | G12C | others | Pemetrexed + carboplatin | No |
| 39 | unknown | others | Nab-paclitaxel + nedaplatin | No |
| 40 | G12A | EGFR-KRAS | No | No |
| 41 | G12D | others | Pemetrexed + carboplatin | Pemetrexed + nedaplatin |
| 42 | G12V | STK11-KRAS | No | No |
| 43 | G12S | others | No | No |
| 44 | G12D | TP53-KRAS | Pemetrexed + carboplatin | No |
| 45 | G12C | others | Nab-paclitaxel + cisplatin | No |
| 46 | G12C | TP53-KRAS | Pemetrexed + cisplatin | No |
| 47 | G12C | others | Pemetrexed | Docetaxel + gemcitabine |
| 48 | G12V | STK11-KRAS | Pemetrexed | No |
| 49 | G12C | TP53-KRAS | Liposome paclitaxel + nedaplatin | Gemcitabine + cisplatin |
| 50 | unknown | others | Pemetrexed | Cisplatin |
| 51 | G12A | STK11-KRAS | Gemcitabine + carboplatin | Pemetrexed + carboplatin |
| 52 | G12C | others | Pemetrexed + nedaplatin | Docetaxel + bevacizumab |
| 53 | G12V | TP53-KRAS | Pemetrexed + carboplatin | No |
| 54 | unknown | EGFR-KRAS | No | Nab-paclitaxel + carboplatin |
| 55 | G12D | others | No | No |
| 56 | unknown | TP53-KRAS | Paclitaxel + carboplatin | No |
| 57 | unknown | others | Gemcitabine + cisplatin | Nab-paclitaxel + lopaplatin |
| 58 | G12D | STK11-KRAS | Paclitaxel + carboplatin | No |
| 59 | G12A | others | No | No |
| 60 | G12V | TP53-KRAS | Pemetrexed + cisplatin | Paclitaxel + carboplatin |
| 61 | unknown | TP53-KRAS | Pemetrexed + carboplatin | Vinorelbine |
| 62 | G12A | EGFR-KRAS | No | No |
| 63 | G12C | others | Pemetrexed | Docetaxel |
| 64 | unknown | others | Pemetrexed + carboplatin | Docetaxel + bevacizumab |
| 65 | unknown | EGFR-KRAS | Pemetrexed + nedaplatin | No |
| 66 | G12C | others | Pemetrexed + nedaplatin | Docetaxel + lopaplatin |
| 67 | G12C | TP53-KRAS | Pemetrexed + carboplatin + bevacizumab | No |
| 68 | G12D | others | No | No |
| 69 | G12A | others | No | No |
| 70 | G12A | others | No | No |
| 71 | G12V | TP53-KRAS | Pemetrexed + nedaplatin | Nab-paclitaxel + nedaplatin |
| 72 | G13S | others | Pemetrexed + cisplatin | No |
| 73 | G12D | TP53-KRAS | Pemetrexed + nedaplatin + bevacizumab | No |
| 74 | G12C | others | Pemetrexed + carboplatin + bevacizumab | Nab-paclitaxel + carboplatin + bevacizumab |
| 75 | G12V | others | No | No |