Table 2.

Recent applications of metabolomics in elucidating beneficial-microbe metabolome changes during plant-microbes symbiosis.

Profiled metabolome: interacting beneficial microbe	Interactions and study conditions	Significant metabolites identified	Metabolomic analytical resource	References
a. Marine-adapted fungal isolates (Emericellopsis sp.; Hypoxylon sp.; Alternaria sp.; Acremonium sp., and Cosmospora sp.);	a. Beneficial marine-adapted fungal isolates + phytopathogen (P. syringae and R. solanacearum); in vitro;	a. Mitorubrinol, mitorubrinic acid, cytochalasins, emerimicins, cephalosporins, ophiobolins and zervamicin;	a. UPLC–QTOF–HRMS/MS;	a. [71];
b. S. cerevisiae;	b. Beneficial microbe (S. cerevisiae) + xenobiotics (copper); in vitro;	b. Glutathione, l-Dihydroorotiacid and l-aspartic acid;	b. LC-MS;	b. [70]
c. Pseudomonads (P. fluorescens RA12, P. protegens Pf-5, P. putida KT2440, and P. putida S12); and	c. Beneficial microbe (Pseudomonads) + growth inhibitor (glyphosate); in vitro; and	c. Tryptophan, phenylalanine, shikimate-3-phosphate, citrulline, thymidine, fumarate, valine, glutamine, and ornithine; and	c. 13C-assisted LC-MS; and	c. [88]; and
d. Trichoderma asperellum	d. Beneficial microbe T. asperellum + phytopathogen (Phytophthora capsici); in vitro	d. Viridepyronone, virone, koninginin D, gliotoxin, and acetyltetrahydroxyanthraquinone	d. HPLC and LC-ESI-MS	d. [89]

Key: UHP: Ultra-High Performance; QTOF: Quadruple Time of Flight; LC: Liquid Chromatography; HR: High Resolution; MS: Mass spectrometry; ESI: Electrospray ionization.