FIGURE 4.

Overall fold of WT PE-H (PDB code 6SBN) in cartoon representation. The short stretch (aa 286–291) is not visible (gray dashed line). The α/β-fold consists of a central twisted β-sheet composed of 9 β-strands flanked by 7 α-helices on both sides. The extended loop region and the Cys residues (ball-and-sticks) forming the disulfide bonds are highlighted in orange. Residues building the catalytic triad are shown as gray ball-and-sticks with labels. Rotations between the structure depictions are indicated in Supplementary Figure S4.