Table 1.

Results of the association analysis using recessive (a) single- and (b) multi-locus linear mixed-effect models for ADAOO in 71 patients with PSEN1 E280A Alzheimer’s disease

(a)
Chr	SNPa	Position	Gene	Marker Information				Single-locus linear mixed-effects model
				Ref/Alt	MAF	CR	Change	$\widehat{\mathbf{\beta }}\left({\mathbf{SE}}_{\widehat{\mathbf{\beta }}}\right)$	P	PFDR
3	rs9809384	111,981,878	SL9C1	T/C	0.32	1	p.Ile364Val	9.73 (1.61)	8.06 × 10−8	1.8 × 10−3
3	rs9809404	111,981,924	SL9C1	T/C	0.29	1	p.Ile348Met	10.85 (1.80)	8.13 × 10−8	9.2 × 10−4
(b)
Chr	SNPa	Position	Gene	Marker Information				Multi-locus linear mixed-effects model
				Ref/Alt	MAF	CR	Change	$\widehat{\mathbf{\beta }}\left({\mathbf{SE}}_{\widehat{\mathbf{\beta }}}\right)$	P	PFDR
3	rs9809384	111,981,878	SLC9C1	T/C	0.32	1	p.Ile364Val	11.03 (1.06)	1.77 × 10−15	4.05 × 10−11
4	rs10030475	70,807,771	CSN1S1	C/T	0.42	0.97	p.Ala117Val	6.37 (0.94)	4.76 × 10−9	5.43 × 10−5
10	rs33995374	100,020,880	LOXL4	C/T	0.2	0.98	p.Arg154Gln	8.80 (1.55)	3.28 × 10−7	2.4 × 10−3
14	rs2273946	24,458,162	DHRS4L2	G/C	0.32	0.98	p.Gln2His	-8.13 (1.43)	3.48 × 10−7	1.9 × 10−3

^aUCSC GRCh37/hg19 coordinates. AOO, age of onset; Chr, chromosome; SNP, single-nucleotide polymorphism; Ref/Alt, reference/alternate allele; MAF, minimum allele frequency; CR, call rate; $\widehat{\beta }$, regression coefficient; ${\mathrm{SE}}_{\widehat{\beta }}$, standard error of $\widehat{\beta }$; P , P value; FDR, false discovery rate. Highlighted variants accelerate ADAOO