Table 3.

Statistically significant biological relatedness between AD core genes and those (target genes) identified as ADAOO modifiers

AD gene	Target	Distancea	P	Route
APOE	CSN1S1	6.0	0.0109	APOE [1.25] CSNK2A1 [1.76] CSN1S1
CLU	CSN1S1	7.0	0.0226	CLU [1.755] CUL1 [1.74] CSN1S1
APP	DHRS4L2	10.2	0.0274	APP [1.74] UBC [3.38] DHRS4L2
APP	LOXL4	10.2	0.0279	APP [1.74] UBC [3.38] LOXL4
CLU	SLC9C1	17.6	0.0289	CLU [1.25] HRAS [1.25] BRAP [3.37] SLC9C1
APOE	DHRS4L2	10.2	0.0329	APOE [1.74 ]UBC [3.38] DHRS4L2
APOE	LOXL4	10.2	0.0335	APOE [1.74] UBC [3.38] LOXL4

^aCalculated as in Itan et al. [34]. AD, Alzheimer’s disease; APOE = apolipoprotein E; APP, amyloid beta precursor protein; BRAP, BRCA1 associated protein; CLU, clusterin; CSN1S1, casein alpha S1; CSNK2A1, casein kinase 2 alpha 1; DHRS4L2, dehydrogenase/reductase 4 Like 2; HRAS, HRas proto-oncogene, GTPase; LOXL4, lysyl oxidase like 4; SLC9C1, solute carrier family 9 member C1; UBC, ubiquitin C; P, P value. Values within [] correspond to the direct biological distance between genes. For more details, see the “Materials and Methods” section in [34]