Table 7.
Absolute and relative risk of death from breast cancer according to gene expression levels of MRPS23, METABRIC data
| Mean probe MRPS23, quartiles | Mean probe MRPS23 | ||||||
|---|---|---|---|---|---|---|---|
| Quartile 1a | Quartile 2b | Quartile 3c | Quartile 4d | Quartile 1–3 | Quartile 4 | ||
| Cum. risk after 5 years (%) (95% CI) | 14 (11–18) | 11 (8–15) | 15 (12–20) | 14 (11–18) | 14 (12–16) | 14 (11–18) | |
| Cum. risk after 10 years (%) (95% CI) | 25 (20–30) | 23 (19–29) | 29 (24–34) | 24 (20–30) | 26 (23–29) | 24 (20–30) | |
| HR, unadjusted (95% CI) | 1 | 1.0 (0.7–1.3) | 1.2 (0.9–1.6) | 1.0 (0.7–1.3) | 1 | 0.9 (0.7–1.2) | |
| HR, adjusted for age (95% CI) | 1 | 1.0 (0.7–1.4) | 1.2 (0.9–1.6) | 1.0 (0.7–1.4) | 1 | 0.9 (0.7–1.2) | |
| HR, adjusted for grade (95% CI) | 1 | 1.0 (0.7–1.4) | 1.2 (0.9–1.6) | 0.9 (0.7–1.2) | 1 | 0.8 (0.7–1.1) | |
Cum. risk cumulative risk, CI confidence interval, HR hazard ratio; Luminal A, Luminal B and HER2-type included in analyses
aMean probe MRPS23 ≤ 7.80
bMean probe MRPS23 > 7.80, ≤ 8.05
cMean probe MRPS23 > 8.05, ≤ 8.31
dMean probe MRPS23 > 8.31