Fig. 6.

Dendritic spines in YFP+ pyramidal neurons in the frontal cortex. (a) Representative photographs of dendritic spines on apical proximal dendrites of frontal cortex pyramidal neurons in WBS (top) and WT (bottom) mice are shown. (b) A significant reduction (p = 0.015) in spine density was found in apical dendrites of WBS mice (N = 6 mice/genotype). (c) Spines in apical dendrites of WBS mice were significantly shorter (p = 0.005) when compared with WT mice (N = 518–689 spines, 6 mice/genotype). Data are presented as mean ± SEM. p values are shown with asterisks indicating values that they are significantly different (Mann–Whitney U test . *p < 0.05; **p < 0.01)