Table 3.
Prediction of BRCA1 germline mutation status among ER negative tumours by multiple logistic regression.
| Cohort 2 | Adjusted model, n = 87 | ||
|---|---|---|---|
| Variables | OR | 95% CI | P-value |
| Mitotic count | 0.543 | ||
| Low, ≤12.2 | 1 | ||
| High, >12.2 | 1.33 | 0.53, 3.33 | |
| p53 | 0.228 | ||
| Low score, ≤3 | 1 | ||
| High score, >3 | 1.78 | 0.70, 4.56 | |
| CK5/6 | 0.684 | ||
| Neg, score = 0 | 1 | ||
| Pos, score >0 | 1.22 | 0.47, 3.13 | |
| Stathmin | 0.002 | ||
| Low score, ≤4 | 1 | ||
| High score, >4 | —a | — | |
Cohort 2 (n = 198). n: number of cases; OR: odds ratio; CI: confidence interval, CK5/6: cytokeratin 5/6. aOdds ratio could not be calculated due to zero stathmin low cases in the BRCA1 positive group.