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. 2020 Feb 19;10:2964. doi: 10.1038/s41598-020-59746-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Effects of Apatinib on the phosphorylation of various growth factor-stimulated receptors at the cellular level detected by Western blot analysis. Phosphorylation of Akt, ERK, PI3K and P38 was suppressed by Apatinib in a dose-dependent manner, and the suppression was more significant in the hypoxic environment, the Western Blot original data are shown in the supplementary information. (B) immunofluorescence data of HUVEC treated with Apatinib, P > 0.05 in group A vs E and P < 0.05 in group B vs F, C vs G, D vs H. Each point represents the mean ± SD (n = 3).