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. 2020 Feb 19;11:964. doi: 10.1038/s41467-020-14762-7

Fig. 7. De novo oligodendrocyte generation is required to promote functional recovery induced by environmental enrichment.

Fig. 7

a Experimental paradigm. Mice received tamoxifen once daily from P13 to P17. b Experimental groups. c Quantitative PCR for MyRF mRNA levels in white matter of wild-type (MyRF+/+, n = 4) and knockdown (MyRFfl/fl, n = 6) mice at P30 (two-tailed unpaired t test, ****p < 0.0001). d Quantification of total YFP + CC1 + OLs at P45 (n = 4 per group) (from left to right: *p = 0.015, **p = 0.009, **p = 0.002). e, f Quantification of foot slips on 2-cm inclined beam (*p = 0.04, **p = 0.003, ****p < 0.0001) (e) and 1-cm inclined beam (*p = 0.04, ****p < 0.0001) (f) at P45 (MyRF+/+ HX Control, n = 11 animals; MyRF+/+ HX-EE Control, n = 9 animals; MyRFfl/fl HX Experimental, n = 12 animals; MyRFfl/fl HX-EE Experimental, n = 10 animals). Data are expressed as mean ± SEM. One-way ANOVA followed by a Tukey’s post hoc test for multiple comparisons was used to compare differences between groups. Source data are provided as a Source Data file.