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. 2020 Feb 19;11(2):134. doi: 10.1038/s41419-020-2328-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Samples from normal skin and psoriatic lesions were stained with RIPK1, RIPK3, MLKL, and pMLKL(S358). Representative images are shown. Scale bar represents 200 μm. b mRNA levels of RIPK1, RIPK3, and MLKL in skin tissues from the normal and psoriasis groups were analyzed by real-time quantitative PCR. c, d Protein levels of RIPK1, RIPK3, pRIPK3(S227), MLKL and pMLKL (S358) were quantified by western blotting. GAPDH was used as a loading control. Relative protein expression was normalized to that of the internal control. Results are representative of three independent experiments. Error bars (b, d) represent mean ± standard deviation (SD). *p < 0.05, **p < 0.01, and ***p < 0.001 when compared.